{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:05:18Z","timestamp":1788923118719,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Tachyphylaxis or acute tolerance to local anaesthetics has been reported, but the prevalence in clinical analgesia is obscure, and the mechanisms behind this phenomenon remain unclear. We sought to examine the clinical significance of tachyphylaxis from the available literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic review of the literature utilising the databases PubMed and Embase employing the search terms [Tachyphylaxis <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> Local Anaesthetics <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> Human] <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> [Tolerance <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> Local Anaesthetics <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> Human].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 66 records were identified. Thirty\u2010four articles were assessed in full text for eligibility. Twenty studies were considered relevant for qualitative analyses, but only six studies were randomised controlled trials. Because of the heterogeneity of the randomised controlled trials, it was not possible to conduct a meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Studies documenting tachyphylaxis with clinical use of local anaesthetics are surprisingly scarce, and the mechanisms behind it remain unclear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12631","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T05:30:35Z","timestamp":1441949435000},"page":"6-14","source":"Crossref","is-referenced-by-count":12,"title":["Tachyphylaxis to local anaesthetics. What is the clinical evidence? A systematic review"],"prefix":"10.1111","volume":"60","author":[{"given":"U. 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