{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:32:04Z","timestamp":1768822324909,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T00:00:00Z","timestamp":1444953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 58\u2010year\u2010old male was scheduled to undergo radical gastrectomy for cancer under general anesthesia. The patient developed agitation and irregular breathing after receiving a single dose of atropine (0.5 mg) to treat bradycardia immediately prior to induction of anesthesia. Within 5 min after the atropine injection, the patient became unresponsive with facial flushing and diaphoresis. When a drop in oxygen saturation was observed, a laryngeal mask airway was inserted after administering a small bolus dose of propofol (80 mg) and the patient was ventilated with 100% oxygen. Physostigmine was not administered because of the relatively low dose of atropine and the fact that his symptoms were not totally consistent with central anticholinergic syndrome (<jats:styled-content style=\"fixed-case\">CAS<\/jats:styled-content>). The differential diagnosis at the time also included an acute cardiovascular event and an idiosyncratic reaction to atropine. The patient fully recovered within 80 min from this highly unusual reaction to a single 0.5 mg <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> dose of atropine.<\/jats:p>","DOI":"10.1111\/aas.12638","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T09:31:32Z","timestamp":1444987892000},"page":"270-273","source":"Crossref","is-referenced-by-count":4,"title":["Central anticholinergic syndrome vs. idiosyncratic reaction triggered by a small <scp>IV<\/scp> dose of atropine"],"prefix":"10.1111","volume":"60","author":[{"given":"X.","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology the First Affiliated Hospital China Medical University Shenyang China"},{"name":"Department of Anesthesiology Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the First Affiliated Hospital China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. F.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Cedars\u2010Sinai Medical Center Los Angeles CA USA"},{"name":"The White Mountain Institute The Sea Ranch CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Cedars\u2010Sinai Medical Center Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology the First Affiliated Hospital China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,16]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2346.1997.00074.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134796.83697.CD"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2346.1997.00004.x"},{"key":"e_1_2_4_5_1","first-page":"219","article-title":"Central anticholinergic syndrome (CAS) in anesthesia and intensive care","volume":"40","author":"Schneck HJ","year":"1989","journal-title":"Acta Anaesthesiol Belg"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.4045\/tidsskr.13.0335"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199112000-00036"},{"key":"e_1_2_4_8_1","first-page":"610","article-title":"Central Anticholinergic Syndrome due to Hypoxia\u2010Induced Bradycardia in a Child with Difficult Intubation Undergoing Complete Dental Restoration: A Case Report","volume":"11","author":"Gharavifard M","year":"2014","journal-title":"J Dent"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488612800492799"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jopan.2007.05.006"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200403000-00010"},{"key":"e_1_2_4_12_1","first-page":"47","article-title":"Central anticholinergic syndrome\u2010The forgotten diagnosis?","volume":"20","author":"Tortline RL","year":"1993","journal-title":"Anesthesiol Rev"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-003-0486-y"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0265021507001159"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12638","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:04:44Z","timestamp":1695539084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,16]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/aas.12638"],"URL":"https:\/\/doi.org\/10.1111\/aas.12638","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,16]]}}}