{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:11:12Z","timestamp":1790111472554,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T00:00:00Z","timestamp":1444262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Breast cancer patients treated with axillary lymph node dissection (<jats:styled-content style=\"fixed-case\">ALND<\/jats:styled-content>) have a higher risk of both acute and persistent pain than those treated with sentinel lymph node biopsy (<jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content>). This could be attributed to a higher risk of nerve injury with <jats:styled-content style=\"fixed-case\">ALND<\/jats:styled-content>. We hypothesized that (1) pain patients have more pronounced sensory dysfunction than pain\u2010free patients, (2) <jats:styled-content style=\"fixed-case\">ALND<\/jats:styled-content> have more sensory dysfunction and pain than <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content> patients and (3) patients with preserved intercostobrachial nerve (<jats:styled-content style=\"fixed-case\">ICBN<\/jats:styled-content>) preservation have less sensory dysfunction compared to a sectioned <jats:styled-content style=\"fixed-case\">ICBN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010seven patients treated with <jats:styled-content style=\"fixed-case\">ALND<\/jats:styled-content> and 27 with <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content> examined with a standardized Quantitative Sensory Testing (<jats:styled-content style=\"fixed-case\">QST<\/jats:styled-content>) protocol, including sensory mapping, mechanical and thermal thresholds, as well as recording intraoperative <jats:styled-content style=\"fixed-case\">ICBN<\/jats:styled-content> handling and pain status 1 week post\u2010operative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The area of cold hypoaesthesia was significantly associated with movement\u2010related pain (<jats:italic>P<\/jats:italic> = 0.004), with a similar tendency for warmth (<jats:italic>P<\/jats:italic> = 0.018) and brush (<jats:italic>P<\/jats:italic> = 0.030) hypoaesthesia areas. 14 (26%) of the patients had moderate\/severe pain at rest and 13 (24%) during movement without differences between <jats:styled-content style=\"fixed-case\">ALND<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content>, but <jats:styled-content style=\"fixed-case\">ALND<\/jats:styled-content> was associated with more sensory dysfunction than <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content>. Patients with sectioned <jats:styled-content style=\"fixed-case\">ICBN<\/jats:styled-content> reported lower pain intensity than those with preserved <jats:styled-content style=\"fixed-case\">ICBN<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.005), but without differences in sensory dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pain was increased in patients having larger areas of hypoaesthesia and reduced in patients where <jats:styled-content style=\"fixed-case\">ICBN<\/jats:styled-content>\u2010section was done. Sensory dysfunction was related to extent of axillary surgery, but not with <jats:styled-content style=\"fixed-case\">ICBN<\/jats:styled-content> handling. Our data suggest that acute pain after breast cancer surgery may be related to nerve injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12641","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T09:54:44Z","timestamp":1444298084000},"page":"259-269","source":"Crossref","is-referenced-by-count":20,"title":["Association between sensory dysfunction and pain 1 week after breast cancer surgery: a psychophysical study"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8371-2326","authenticated-orcid":false,"given":"K. G.","family":"Andersen","sequence":"first","affiliation":[{"name":"Section for Surgical Pathophysiology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Breast Surgery Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"Duriaud","sequence":"additional","affiliation":[{"name":"Section for Surgical Pathophysiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. K.","family":"Aasvang","sequence":"additional","affiliation":[{"name":"Section for Surgical Pathophysiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kehlet","sequence":"additional","affiliation":[{"name":"Section for Surgical Pathophysiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f1865"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278795"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.12.005"},{"key":"e_1_2_6_5_1","first-page":"2617689","article-title":"Predictive factors for the development of persistent pain after breast cancer surgery","author":"Andersen KG","year":"2015","journal-title":"Pain"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2013.12.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1097\/AJP.0000000000000156","article-title":"The effect of pain on physical function after breast cancer: development and validation of an assessment tool","volume":"31","author":"Andersen KG","year":"2015","journal-title":"Clin J Pain"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2014.01.014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4741.2003.09505.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00843.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.341"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12393"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68700-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.09.20"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2012.09.013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802059259"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980515)82:10<1904::AID-CNCR13>3.0.CO;2-X"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.7.4.524"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer195"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000136"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181a68c64"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3182261650"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.021"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000129490.67954.C2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.03.020"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2010.01.010"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12641","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:04:11Z","timestamp":1695539051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,8]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/aas.12641"],"URL":"https:\/\/doi.org\/10.1111\/aas.12641","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,8]]}}}