{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:23:57Z","timestamp":1784748237863,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T00:00:00Z","timestamp":1451260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pre\u2010operative opioid use has been suggested to increase post\u2010operative pain and opioid consumption after total knee arthroplasty (\n                      <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>\n                      ), but previous studies are either retrospective or inhomogeneous with regard to surgical procedures or control of analgesic regimes, or with few opioid\u2010treated patients, hindering firm conclusions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a prospective observational study, we investigated the effect of &gt; 4 weeks pre\u2010operative opioid use [none vs. low dose (&lt; 30 mg morphine equivalents (eq.)) vs. high dose (&gt; 30 mg morphine eq.] in patients scheduled for primary, unilateral\n                      <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>\n                      . All patients had well\u2010defined multimodal opioid\u2010sparring perioperative analgesic therapy, and continued any pre\u2010operative opioid medication. The primary outcome was differences between groups in pain at rest and during walk for the first 6 post\u2010operative days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 123 patients included, 115 were available for final analysis (93% follow\u2010up rate). Post\u2010operative pain during walk was significantly increased in both opioid\u2010treated groups vs. non\u2010opioid\u2010treated patients (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.009). Secondary analysis of combining all pre\u2010operatively opioid\u2010treated patients vs. opioid\u2010free patients, showed significantly increased pain at rest and walk and increased post\u2010operative opioid requirement \u2013 excluding pre\u2010operative dosage \u2013 during the first post\u2010operative week in opioid\u2010treated patients (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001 and\n                      <jats:italic>P<\/jats:italic>\n                      = 0.007, respectively\n                      <jats:bold>).<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Pre\u2010operative opioid use increases the risk for post\u2010operative pain at rest and walk, and increased opioid consumption after\n                      <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.12667","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T07:20:39Z","timestamp":1451287239000},"page":"529-536","source":"Crossref","is-referenced-by-count":84,"title":["Chronic pre\u2010operative opioid use and acute pain after fast\u2010track total knee arthroplasty"],"prefix":"10.1111","volume":"60","author":[{"given":"E. K.","family":"Aasvang","sequence":"first","affiliation":[{"name":"Section of Surgical Pathophysiology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"The Lundbeck Centre for fast\u2010track Hip and Knee Arthroplasty Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. H.","family":"Lunn","sequence":"additional","affiliation":[{"name":"The Lundbeck Centre for fast\u2010track Hip and Knee Arthroplasty Copenhagen Denmark"},{"name":"Anesthesiological department Hvidovre Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. B.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Orthopedic department Holstebro Hospital Holstebro Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. W.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Orthopedic department Vejle Hospital Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Solgaard","sequence":"additional","affiliation":[{"name":"Orthopedic department Gentofte Hospital Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kehlet","sequence":"additional","affiliation":[{"name":"Section of Surgical Pathophysiology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"The Lundbeck Centre for fast\u2010track Hip and Knee Arthroplasty Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.01095"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2008.05831.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.06.011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujps.2010.09.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.07.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000197"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.01473"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.02.028"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker343"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.04.003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000278091.29062.63"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2011\/14\/145"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e328335ddfe"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.12.1453"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0160(13)70006-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03318.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2005.08.001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu155"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6719.230"},{"key":"e_1_2_6_22_1","first-page":"CD003115","article-title":"Oral or transdermal opioids for osteoarthritis of the knee or hip","volume":"9","author":"da Costa BR","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.01.003"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket463"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e4148"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-013-2750-2"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-014-2298-x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2009.00653.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.05.015"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq333"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.3810\/psm.2014.05.2053"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000033"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000597"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12667","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12667","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:19:22Z","timestamp":1695482362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,28]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/aas.12667"],"URL":"https:\/\/doi.org\/10.1111\/aas.12667","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726042538.793512742","asserted-by":"object"}]},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,28]]}}}