{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:12:52Z","timestamp":1695622372391},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T00:00:00Z","timestamp":1468108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Background<\/jats:title>Isocapnic hyperventilation (IHV<\/jats:styled-content>) is a method that fastens weaning from inhalation anaesthesia by increasing airway concentration of carbon dioxide (CO<\/jats:styled-content>2<\/jats:sub>) during hyperventilation (HV<\/jats:styled-content>). In an animal model, we evaluated a technique of adding CO<\/jats:styled-content>2<\/jats:sub> directly to the breathing circuit of a standard anaesthesia apparatus.<\/jats:p><\/jats:sec>Methods<\/jats:title>Eight anaesthetised pigs weighing 28 \u00b1 2 kg were intubated and mechanically ventilated. From a baseline ventilation of 5 l\/min, HV<\/jats:styled-content> was achieved by doubling minute volume and fresh gas flow. Respiratory rate was increased from 15 to 22\/min. The CO<\/jats:styled-content>2<\/jats:sub> absorber was disconnected and CO<\/jats:styled-content>2<\/jats:sub> was delivered (DCO<\/jats:styled-content>2<\/jats:sub>) to the inspiratory limb of a standard breathing circuit via a mixing box. Time required to decrease end\u2010tidal sevoflurane concentration from 2.7% to 0.2% was defined as washout time. Respiration and haemodynamics were monitored by blood gas analysis, spirometry, electric impedance tomography and pulse contour analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>A DCO<\/jats:styled-content>2<\/jats:sub> of 261 \u00b1 19 ml\/min was necessary to achieve isocapnia during HV<\/jats:styled-content>. The corresponding FICO<\/jats:styled-content>2<\/jats:sub>\u2010level remained stable at 3.1 \u00b1 0.3%. During IHV<\/jats:styled-content>, washout of sevoflurane was three times faster, 433 \u00b1 135 s vs. 1387 \u00b1 204 s (P<\/jats:italic> < 0.001). Arterial CO<\/jats:styled-content>2<\/jats:sub> tension and end\u2010tidal CO<\/jats:styled-content>2<\/jats:sub>, was 5.2 \u00b1 0.4 kP<\/jats:styled-content>a and 5.6 \u00b1 0.4%, respectively, before IHV<\/jats:styled-content> and 5.1 \u00b1 0.3 kP<\/jats:styled-content>a and 5.7 \u00b1 0.3%, respectively, during IHV<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In this experimental in vivo model of isocapnic hyperventilation, the washout time of sevoflurane anaesthesia was one\u2010third compared to normal ventilation. The method for isocapnic hyperventilation described can potentially be transferred to a clinical setting with the intention to decrease emergence time from inhalation anaesthesia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12761","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T02:46:50Z","timestamp":1468205210000},"page":"1261-1269","source":"Crossref","is-referenced-by-count":3,"title":["Isocapnic hyperventilation shortens washout time for sevoflurane \u2013 an experimental in vivo study"],"prefix":"10.1111","volume":"60","author":[{"given":"K.","family":"Hall\u00e9n","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Institute of Clinical Sciences The Sahlgrenska Academy Gothenburg University Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Stenqvist","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Institute of Clinical Sciences The Sahlgrenska Academy Gothenburg University Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010E.","family":"Ricksten","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Institute of Clinical Sciences The Sahlgrenska Academy Gothenburg University Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lindgren","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Institute of Clinical Sciences The Sahlgrenska Academy Gothenburg University Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"755","article-title":"Accidental severe hypercapnia during anaesthesia. 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