{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:22:05Z","timestamp":1785860525898,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T00:00:00Z","timestamp":1472601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Charit\u00e9 - Universitaetsmedizin Berlin"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010operative delirium and post\u2010operative cognitive dysfunction (<jats:styled-content style=\"fixed-case\">POCD<\/jats:styled-content>) are both common but it has not been clarified how closely they are associated. We aimed to assess the possible relationship in a secondary analysis of data from the \u2018Surgery Depth of anaesthesia and Cognitive outcome\u2019\u2010 study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients aged \u2265 60 years undergoing non\u2010cardiac surgery planned for longer than 60 min. Delirium was assessed according to the Diagnostic and Statistical Manual of Mental Disorders <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> criteria in the post\u2010anaesthesia care unit (<jats:styled-content style=\"fixed-case\">PACU<\/jats:styled-content>) as well as within the first week after surgery. Cognitive function was assessed with a neuropsychological test battery. Multivariable analysis of <jats:styled-content style=\"fixed-case\">POCD<\/jats:styled-content> was performed with consideration of predisposing and precipitating factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1277 randomized patients, 850 (66.6%) had complete data. Delirium was found in 270 patients (32.9% of 850). We detected <jats:styled-content style=\"fixed-case\">POCD<\/jats:styled-content> in 162 (20.9% of 776) at 1 week and in 52 (9.4% of 553) at 3 months. In multivariable analysis (<jats:italic>n<\/jats:italic> = 808), delirium had no overall effect on <jats:styled-content style=\"fixed-case\">POCD<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.30). Patients with no delirium in <jats:styled-content style=\"fixed-case\">PACU<\/jats:styled-content> but with postoperative delirium within 7 days had an increased risk of <jats:styled-content style=\"fixed-case\">POCD<\/jats:styled-content> at 3 months (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 2.56 (95%\u2010confidence interval: 1.07\u20136.16), <jats:italic>P<\/jats:italic> = 0.035). No significant association was found for the other subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is no clear evidence that postoperative delirium is independently associated with <jats:styled-content style=\"fixed-case\">POCD<\/jats:styled-content> up to 3 months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12779","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T07:16:52Z","timestamp":1472627812000},"page":"1404-1414","source":"Crossref","is-referenced-by-count":34,"title":["No convincing association between post\u2010operative delirium and post\u2010operative cognitive dysfunction: a secondary analysis"],"prefix":"10.1111","volume":"60","author":[{"given":"M.","family":"Franck","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Campus\u2010Virchow\u2010Klinikum and Campus Charit\u00e9 Mitte Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Nerlich","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Campus\u2010Virchow\u2010Klinikum and Campus Charit\u00e9 Mitte Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Neuner","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Campus\u2010Virchow\u2010Klinikum and Campus Charit\u00e9 Mitte Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Schlattmann","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Informatics and Documentation University Hospital Jena Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. R.","family":"Brockhaus","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Campus\u2010Virchow\u2010Klinikum and Campus Charit\u00e9 Mitte Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. D.","family":"Spies","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Campus\u2010Virchow\u2010Klinikum and Campus Charit\u00e9 Mitte Charit\u00e9 \u2010 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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