{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:45:58Z","timestamp":1790790358283,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:00:00Z","timestamp":1473206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Corticosteroids are used in paediatric heart surgery to attenuate systemic inflammatory response. Glycocalyx regulates vascular permeability, shear stress and cell adhesion on the endothelium. Syndecan\u20101 serves as a biomarker of glycocalyx degradation. Hydrocortisone decreased endothelial glycocalyx degradation in an experimental model. Our hypothesis was that high\u2010dose methylprednisolone decreases glycocalyx degradation as measured by plasma sydecan\u20101 concentration in children undergoing cardiac surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two double\u2010blinded, randomized, placebo\u2010controlled trials were conducted. In the first trial (\u2018neonatal trial\u2019), 40 neonates undergoing open heart surgery received either 30 mg\/kg intravenous methylprednisolone (<jats:italic>n<\/jats:italic> = 20) or placebo (<jats:italic>n<\/jats:italic> = 20). In the second trial (\u2018<jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content> trial\u2019), 45 infants and very young children, undergoing ventricular or atrioventricular septal defect correction received one of the following: 30 mg\/kg of methylprednisolone intravenously after anaesthesia induction (<jats:italic>n<\/jats:italic> = 15), 30 mg\/kg methylprednisolone in the cardiopulmonary bypass prime solution (<jats:italic>n<\/jats:italic> = 15) or placebo (<jats:italic>n<\/jats:italic> = 15). Plasma syndecan\u20101 concentrations were measured. Results were expressed both as absolute concentrations and in relative concentrations as multiples of the baseline values of syndecan\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no statistically significant differences between the neonate trial groups for absolute syndecan\u20101 concentrations. However, operative administration of methylprednisolone to neonates significantly reduced the relative increases of syndecan\u20101 at weaning from cardiopulmonary bypass (<jats:italic>P<\/jats:italic> = 0.008) and at 6 h post\u2010operatively (<jats:italic>P<\/jats:italic> = 0.018). There were no statistically significant differences in absolute or relative increases of syndecan\u20101 between the <jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content> trial study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010dose methylprednisolone reduces shedding of glycocalyx in neonates after complex cardiac surgery but not in older infants after repair of <jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AVSD<\/jats:styled-content> with shorter ischaemia times.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12785","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T02:13:10Z","timestamp":1473300790000},"page":"1386-1394","source":"Crossref","is-referenced-by-count":25,"title":["High\u2010dose methylprednisolone and endothelial glycocalyx in paediatric heart surgery"],"prefix":"10.1111","volume":"60","author":[{"given":"E.","family":"Pesonen","sequence":"first","affiliation":[{"name":"Division of Anaesthesiology, Peijas Hospital, Department of Anaesthesiology Intensive Care and Pain Medicine University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Keski\u2010Nisula","sequence":"additional","affiliation":[{"name":"Division of Anaesthesiology Children's Hospital Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Children's Hospital University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Palo","sequence":"additional","affiliation":[{"name":"Division of Anaesthesiology Children's Hospital Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Salminen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Children's Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. K.","family":"Suominen","sequence":"additional","affiliation":[{"name":"Division of Anaesthesiology Children's Hospital Department of Anaesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000163678.20704.C5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(00)01082-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.04.035"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg125"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000070955.55636.25"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000063443.32874.60"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-2788-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.08.042"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.948737"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000286984.39328.96"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-008-0749-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mol.0000181325.08926.9c"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq137"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.684852"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659108098215"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.07.063"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659110362822"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659110392438"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0203-y"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/14017431.2012.717303"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.10.013"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00158.2010"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.11.397"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.02.013"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659112442237"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181e453d4"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318210385c"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31829f91fc"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31819c83b5"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182289988"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1398377"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31825b5c10"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12785","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:41:51Z","timestamp":1695501711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,7]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/aas.12785"],"URL":"https:\/\/doi.org\/10.1111\/aas.12785","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,7]]}}}