{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:42:37Z","timestamp":1793396557959,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T00:00:00Z","timestamp":1479772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Local anaesthetics (<jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>) are often suspected as possible causes of allergic reactions. The Danish Anaesthesia Allergy Centre (<jats:styled-content style=\"fixed-case\">DAAC<\/jats:styled-content>) is the national reference centre for investigation of perioperative allergic reactions. The purpose of this study was to investigate the incidence of IgE\u2010mediated immediate type perioperative allergic reactions to <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the period 2004\u20132013, a total of 409 patients (244 women\/165 men; median age 49 years, range 1\u201386 years) were investigated in <jats:styled-content style=\"fixed-case\">DAAC<\/jats:styled-content> on suspicion of allergy associated with anaesthesia and surgery. A total of 162 (40%) patients were exposed to one or more <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>. Suspected allergy to <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> was investigated by prick test, intradermal test and subcutaneous provocation with the suspected drug. Patients with positive skin tests still underwent subcutaneous provocation, as false positive skin tests can occur.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 203 test series with <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> were carried out on 162 patients (89 women\/73 men; mean age 49 years, range 2\u201385 years) with the following drugs: Lidocaine <jats:italic>n<\/jats:italic> = 80 (49%), bupivacaine <jats:italic>n<\/jats:italic> = 82 (51%), ropivacaine <jats:italic>n<\/jats:italic> = 31 (19%) and mepivacaine <jats:italic>n<\/jats:italic> = 10 (6%). All 162 patients had negative subcutaneous provocation for all tested <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u20131.8%). Investigations revealed another allergen in 52 of 162 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>None of the 162 patients with suspected perioperative allergic reactions and exposure to <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> reacted on subcutaneous provocation with the relevant <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>. Thus, no patients have been diagnosed with allergy to <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">DAAC<\/jats:styled-content> in the period 2004\u20132013 and allergy to <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content> must be considered very rare in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12833","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T02:12:53Z","timestamp":1479867173000},"page":"149-155","source":"Crossref","is-referenced-by-count":42,"title":["No cases of perioperative allergy to local anaesthetics in the Danish Anaesthesia Allergy Centre"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4147-0987","authenticated-orcid":false,"given":"A. 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