{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:21:57Z","timestamp":1782206517744,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T00:00:00Z","timestamp":1481587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001786","name":"University of Adelaide","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004267","name":"Royal Adelaide Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004267","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The objectives of this study were to estimate the frequency of occult upper gastrointestinal abnormalities, presence of gastric acid as a contributing factor, and associations with clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were extracted for study participants at a single centre who had an endoscopy performed purely for research purposes and in whom treating physicians were not suspecting gastrointestinal bleeding. Endoscopic data were independently adjudicated by two gastroenterologists who rated the likelihood that observed pathological abnormalities were related to gastric acid secretion using a 3\u2010point ordinal scale (unlikely, possible or probable).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Endoscopy reports were extracted for 74 patients [age 52 (37, 65) years] undergoing endoscopy on day 5 [3, 9] of <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> admission. Abnormalities were found in 25 (34%) subjects: gastritis\/erosions in 10 (14%), nasogastric tube trauma in 8 (11%), oesophagitis in 4 (5%) and non\u2010bleeding duodenal ulceration in 3 (4%). The contribution of acid secretion to observed pathology was rated \u2018probable\u2019 in six subjects (rater #1) and five subjects (rater #2). Prior to endoscopy, 39 (53%) patients were receiving acid\u2010suppressive therapy. The use of acid\u2010suppressive therapy was not associated with the presence of an endoscopic abnormality (present 15\/25 (60%) vs. absent 24\/49 (49%); <jats:italic>P<\/jats:italic> = 0.46). Haemoglobin concentrations, packed red cells transfused and mortality were not associated with mucosal abnormalities (<jats:italic>P<\/jats:italic> = 0.83, <jats:italic>P<\/jats:italic> &gt; 0.9 and <jats:italic>P<\/jats:italic> &gt; 0.9 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Occult mucosal abnormalities were observed in one\u2010third of subjects. The presence of mucosal abnormalities appeared to be independent of prior acid\u2010suppressive therapy and was not associated with reduced haemoglobin concentrations, increased transfusion requirements, or mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12844","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T03:42:41Z","timestamp":1481686961000},"page":"216-223","source":"Crossref","is-referenced-by-count":6,"title":["Occult upper gastrointestinal mucosal abnormalities in critically ill patients"],"prefix":"10.1111","volume":"61","author":[{"given":"C.","family":"Ovenden","sequence":"first","affiliation":[{"name":"Discipline of Acute Care Medicine University of Adelaide Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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Q.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Centre for Research Excellence in Translating Nutritional Science to Good Health Adelaide SA Australia"},{"name":"Discipline of Medicine University of Adelaide Adelaide SA Australia"},{"name":"Department of Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. M.","family":"Weinel","sequence":"additional","affiliation":[{"name":"Department of Critical Care Services Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Finnis","sequence":"additional","affiliation":[{"name":"Discipline of Acute Care Medicine University of Adelaide Adelaide SA Australia"},{"name":"Department of Critical Care Services Royal Adelaide Hospital Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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