{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:32:26Z","timestamp":1759336346773,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010operative pain is common and often severe after open abdominal hysterectomy, and analgesic consumption high. This study assessed the efficacy of local infiltration analgesia (<jats:styled-content style=\"fixed-case\">LIA<\/jats:styled-content>) injected systematically into different tissues during surgery compared with saline on post\u2010operative pain and analgesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010nine patients were randomized to Group <jats:styled-content style=\"fixed-case\">LIA<\/jats:styled-content> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>29) consisting of 156\u00a0ml of a mixture of 0.2% ropivacaine + 30\u00a0mg ketorolac + 0.5\u00a0mg (5 ml) adrenaline, where the drugs were injected systematically in the operating site, around the proximal vagina, the ligaments, in the fascia and subcutaneously, or to saline and intravenous ketorolac, Group C (Control, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>28), in a double\u2010blind study. Post\u2010operative pain, analgesic consumption, side\u2010effects, and home discharge were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median dose of rescue morphine given 0\u201324\u00a0h after surgery was significantly lower in group <jats:styled-content style=\"fixed-case\">LIA<\/jats:styled-content> (18\u00a0mg, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 5\u201325\u00a0mg) compared with group C (27\u00a0mg, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 15\u201343\u00a0mg, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.028). Median time to first analgesic injection was significantly longer in group <jats:styled-content style=\"fixed-case\">LIA<\/jats:styled-content> (40\u00a0min, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 20\u201360\u00a0min) compared with group C (20\u00a0min, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 12\u201330\u00a0min, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.009). <jats:styled-content style=\"fixed-case\">NRS<\/jats:styled-content> score was lower in the group <jats:styled-content style=\"fixed-case\">LIA<\/jats:styled-content> compared with group C in the direct post\u2010operative period (0\u20132\u00a0h). No differences were found in post\u2010operative side\u2010effects or home discharge between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Systematically injected local infiltration analgesia for pain management was superior to saline in the primary endpoint, resulting in significantly lower rescue morphine requirements during 0\u201324\u00a0h, longer time to first analgesic request and lower early post\u2010operative pain intensity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12883","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T15:09:29Z","timestamp":1491404969000},"page":"539-548","source":"Crossref","is-referenced-by-count":12,"title":["Post\u2010operative pain relief using local infiltration analgesia during open abdominal hysterectomy: a randomized, double\u2010blind study"],"prefix":"10.1111","volume":"61","author":[{"given":"J. M.","family":"Hayden","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Institute of Clinical sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8890-6752","authenticated-orcid":false,"given":"J.","family":"Oras","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Institute of Clinical sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. I.","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Institute of Clinical sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. G.","family":"Olausson","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Institute of Clinical sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010E.","family":"Th\u00f6rn","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Institute of Clinical sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Pharmacology Karolinska Institutet, Karolinska University Hospital Stockholm, Solna Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,3]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Swedish Association of Obstetrics and Gynaecology (SFOG) 2011. 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