{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:57:10Z","timestamp":1759939030151,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001424","name":"American Liver Foundation","doi-asserted-by":"publisher","award":["20150224"],"award-info":[{"award-number":["20150224"]}],"id":[{"id":"10.13039\/100001424","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There is increasing interest in the use of intranasal naloxone to reverse adverse opioid effects during management of procedural pain in children and in adults after overdose. There are limited data on the pharmacokinetics of intranasal naloxone so in this study we aimed to detail the pharmacokinetic profile of the commercially marketed injectable solution of naloxone 0.4 mg\/ml when administered as an intranasal spray.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty healthy volunteers received naloxone as an intranasal spray at a dose of 10 \u03bcg\/kg. Venous blood sampling was carried out for 90 min after administration to determine the time profile of the plasma concentrations of using tandem mass spectrometry. Pharmacokinetic parameters were calculated using a one\u2010compartment model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median time to maximum naloxone concentration (Tmax) was 14.5 (95% CI: 9.0\u201316.5) min, mean maximum naloxone concentration (Cmax) was 1.09 \u00b1 0.56 ng\/ml and mean AUC<jats:sub>0\u201390 min<\/jats:sub> was 37.1 \u00b1 15.0 ng*min\/ml. Elimination half\u2010life estimated from the median concentration data was 28.2 min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show a faster uptake of intranasal naloxone to maximum concentration compared with previous studies although with a marked variation in maximum concentration. The findings are consistent with our clinical experience of the time profile for reversing the effects of sufentanil sedation in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12898","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T07:38:15Z","timestamp":1493192295000},"page":"636-640","source":"Crossref","is-referenced-by-count":16,"title":["Pharmacokinetics after a single dose of naloxone administered as a nasal spray in healthy volunteers"],"prefix":"10.1111","volume":"61","author":[{"given":"E.","family":"Vanky","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care Visby Hospital Visby Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hellmundt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Anesthesia and Intensive Care Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Bondesson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Environment and Feed Hygiene National Veterinary Institute (SVA) Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Eksborg","sequence":"additional","affiliation":[{"name":"Childhood Cancer Research Unit Department of Woman and Child Health Karolinska University Hospital Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2273-2942","authenticated-orcid":false,"given":"S.","family":"Lundeberg","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Visby Hospital Visby Sweden"},{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,25]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.5114\/aoms.2014.42584"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1016\/j.ajem.2012.10.004"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1111\/j.1360-0443.2009.02724.x"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1080\/07448481.2016.1277730"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1007\/s13346-012-0092-0"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1007\/s13346-012-0108-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/FTD.0b013e3181816214","article-title":"Population pharmacokinetics of intravenous, intramuscular and intranasal naloxone in human volunteers","volume":"30","author":"Dowling J","year":"2008","journal-title":"Ther Drug Monit"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1002\/jcph.759"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1007\/s00228-016-2191-1"},{"key":"e_1_2_7_11_1","first-page":"49","volume-title":"Applied nonparametric statistics","author":"Daniel WW","year":"1990"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:33:33Z","timestamp":1695573213000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,25]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/aas.12898"],"URL":"https:\/\/doi.org\/10.1111\/aas.12898","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"type":"print","value":"0001-5172"},{"type":"electronic","value":"1399-6576"}],"subject":[],"published":{"date-parts":[[2017,4,25]]}}}