{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:20:47Z","timestamp":1787239247542,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pre\u2010operative identification of high\u2010pain responders for acute pain after total knee arthroplasty (\n                      <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>\n                      ) could lead to targeted analgesic trials and individualized analgesic strategies to improve recovery and potentially reduce the risk of persistent post\u2010surgical pain. The aim of this study was to use simple clinical tests and questionnaires to identify predictive nociceptive and psychological factors for acute post\u2010\n                      <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>\n                      pain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty consecutive\n                      <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>\n                      patients were included in a prospective descriptive study of pain during a 5\u2010m walk\u2010test 24\u00a0h post\u2010operatively as the primary outcome. Predictive variables collected prior to surgery included demographics, nociceptive testing (pressure pain threshold (\n                      <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>\n                      ), cold pressor tolerance, electrical pain threshold and tolerance) and psychological profile (pain catastrophizing scale (\n                      <jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content>\n                      ) and hospital anxiety and depression scale). The prediction of acute post\u2010\n                      <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>\n                      pain was assessed by univariate analysis, logistic regressions and\n                      <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>\n                      curves.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Reduced\n                      <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>\n                      on the arm and increased\n                      <jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content>\n                      were predictive variables for moderate\/severe post\u2010\n                      <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>\n                      pain 24\u00a0h after surgery (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.026, respectively, R\u2010squared 0.21) in the logistic regression model. Odds ratios were 0.67 for a 50\n                      <jats:styled-content style=\"fixed-case\">kP<\/jats:styled-content>\n                      a increased\n                      <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>\n                      and 1.36 for a 5\u00a0point increase in\n                      <jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content>\n                      . A predictive model with cut\u2010off values of\n                      <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>\n                      \u00a0\u2264\u00a0245\n                      <jats:styled-content style=\"fixed-case\">kP<\/jats:styled-content>\n                      a and\n                      <jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content>\n                      \u2265\u00a08 point had a sensitivity of 71.4 and a specificity of 62.5.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Pre\u2010operative widespread pressure pain hypersensitivity and pain catastrophizing are predictive of moderate severe post\u2010\n                      <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>\n                      pain. If validated in a larger population, the clinically applicable tests should be considered in future interventions aiming to minimize post\u2010operative pain in high\u2010risk patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.12899","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T01:12:44Z","timestamp":1494897164000},"page":"676-687","source":"Crossref","is-referenced-by-count":39,"title":["Clinical, nociceptive and psychological profiling to predict acute pain after total knee arthroplasty"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0248-4489","authenticated-orcid":false,"given":"I. E.","family":"Luna","sequence":"first","affiliation":[{"name":"Section\u00a0of Surgical Pathophysiology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"The Lundbeck Centre for fast\u2010track Hip and Knee Arthroplasty Copenhagen Denmark"},{"name":"Department of Orthopaedics Gentofte\u2010Herlev Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kehlet","sequence":"additional","affiliation":[{"name":"Section\u00a0of Surgical Pathophysiology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"The Lundbeck Centre for fast\u2010track Hip and Knee Arthroplasty Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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