{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:46Z","timestamp":1787013766328,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the landscape of early extubation, and identify factors associated with early extubation (\u2264\u00a024\u00a0h) after superior cavopulmonary connection (stage 2 operation) among children with single ventricle anatomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients undergoing stage 2 operation after Norwood operation from the Pediatric Heart Network Single Ventricle Reconstruction (\n                      <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>\n                      ) trial public\u2010use dataset were included. Elastic net regularized logistic regression models were fitted to evaluate the factors associated with early extubation after stage 2 operation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 390 patients from 15 North American centers qualified for inclusion. Of these, 42 patients (10.8%) were extubated in operating room, 151 patients (38.7%) were extubated outside the operating room within the first 24\u00a0h after stage 2 operation, and the remaining 197 patients (50.5%) required mechanical ventilation for &gt;\u00a024\u00a0h. In adjusted models, factors associated with early extubation after stage 2 operation were elective timing of stage 2 operation, lower incidence of post\u2010Norwood complications, shorter\n                      <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>\n                      duration for stage 2 operation, and no cardiac catheterization after Stage 2 operation. We also performed multiple other alternative analyses to identify factors associated with early extubation that demonstrated same associations as the primary model. The mean hospital length of stay after Stage 2 operation was 20% shorter among patients with early extubation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Data from this large multicenter study demonstrate that approximately one\u2010half of the patients undergoing operation for superior cavopulmonary connection are extubated within 24\u00a0h after heart operation. Furthermore, early extubation is associated with shorter hospital length of stay.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.12915","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T04:36:40Z","timestamp":1496291800000},"page":"722-729","source":"Crossref","is-referenced-by-count":14,"title":["Factors associated with early extubation after superior cavopulmonary connection: analysis from single ventricle reconstruction trial"],"prefix":"10.1111","volume":"61","author":[{"given":"D.","family":"Zakaria","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rettiganti","sequence":"additional","affiliation":[{"name":"Biostatistics Program Department of Pediatrics University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Gossett","sequence":"additional","affiliation":[{"name":"Biostatistics Program Department of Pediatrics University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1764-3910","authenticated-orcid":false,"given":"P.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.06.093"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.11.042"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2009.06.039"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)01306-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2003.01.015"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.05.033"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951112002181"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-014-1003-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0670-z"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912461"},{"key":"e_1_2_9_12_1","unstructured":"Pediatric Heart Network.The Pediatric Heart Network. 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