{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:22:44Z","timestamp":1779211364374,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Ketamine has been used as part of the multimodal analgesia technique in the acute perioperative period. The effect of perioperative intravenous small\u2010dose ketamine on the quality of recovery from the patient point\u2010of\u2010view has not been assessed. We hypothesized that low\u2010dose ketamine would enhance recovery following laparoscopic cholecystectomy under total intravenous anesthesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred thirty five patients undergoing laparoscopic cholecystectomy were enrolled in this randomized, double\u2010blind placebo\u2010controlled trial. Subjects were randomly assigned to one of three groups: saline, ketamine 0.2\u00a0mg\/kg, or ketamine 0.4\u00a0mg\/kg immediately following the induction of anesthesia and before skin incision. The primary endpoint was assessed using the Quality of Recovery Questionnaire (QoR\u201040), a 40\u2010item quality of recovery scoring system. In addition, early clinical recovery variables, such as time to eye opening, occurrence of nausea and vomiting, pain score, analgesic use, and length of PACU stay were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differences were detected in the total or individual dimension scores of the QoR\u201040 questionnaire. The incidence of nausea, vomiting, and other complications did not differ among the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Small doses of ketamine do not improve the quality of recovery after remifentanil\u2010based anesthesia for laparoscopic cholecystectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12919","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T03:26:39Z","timestamp":1497583599000},"page":"740-748","source":"Crossref","is-referenced-by-count":37,"title":["Ketamine does not enhance the quality of recovery following laparoscopic cholecystectomy: a randomized controlled trial"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-4111","authenticated-orcid":false,"given":"E. T.","family":"Moro","sequence":"first","affiliation":[{"name":"Department of Surgery School of Medical and Health Sciences Pontifical Catholic University of S\u00e3o Paulo, PUC\u2010SP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. M. P. S. S.","family":"Feitosa","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medical and Health Sciences Pontifical Catholic University of S\u00e3o Paulo, PUC\u2010SP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. G.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medical and Health Sciences Pontifical Catholic University of S\u00e3o Paulo, PUC\u2010SP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. F. P.","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Medical and Health Sciences Pontifical Catholic University of S\u00e3o Paulo, PUC\u2010SP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Rosalino","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences Pontifical Catholic University of S\u00e3o Paulo, PUC\u2010SP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. P.","family":"Marossi","sequence":"additional","affiliation":[{"name":"School of Medical and Health Sciences Pontifical Catholic University of S\u00e3o Paulo, PUC\u2010SP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Bloomstone","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology College of Medicine University of Arizona Phoenix AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H. C.","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Botucatu Medical School S\u00e3o Paulo State University, UNESP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkr027"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e328330373a"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31823c1030"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200501000-00030"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000105911.66089.59"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12377"},{"key":"e_1_2_7_8_1","first-page":"2504","article-title":"Morphine with adjuvant ketamine versus higher dose of morphine alone for acute pain: a meta\u2010analysis","volume":"15","author":"Ding X","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13306"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12619"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bja.a013366"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182334d8b"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.860019"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31822c9a59"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1997.tb04854.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200006000-00020"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00278-0"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200006000-00031"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2015.02.002"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12417"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0265021505000724"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2004.00399.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200207000-00018"},{"key":"e_1_2_7_25_1","first-page":"583","article-title":"Preemptive low\u2010dose of ketamine does not effective on anesthetic consumption, perioperative analgesic requirement and postoperative pain, nausea and vomiting in painful ophthalmic surgery","volume":"18","author":"Abdolahi M","year":"2013","journal-title":"J Res Med Sci"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00044-5"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-8-200404200-00010"},{"key":"e_1_2_7_28_1","first-page":"42","article-title":"The use of opioid adjuvants in perioperative multimodal analgesia","volume":"44","author":"Zukowski M","year":"2012","journal-title":"Anaesthesiol Intensive Ther"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000137441.79168.C5"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200110000-00013"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12919","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:59:52Z","timestamp":1695560392000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,15]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/aas.12919"],"URL":"https:\/\/doi.org\/10.1111\/aas.12919","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,15]]}}}