{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:39:59Z","timestamp":1782322799187,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010operative catheter\u2010related bladder discomfort (CRBD) causes increased emergence agitation. Muscarinic receptor activation is a major mechanism in CRBD development. Experimental studies showed that sevoflurane has anti\u2010muscarinic effects whereas propofol does not. Our hypothesis was that sevoflurane anaesthesia would reduce the incidence of CRBD following bladder surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 82 patients undergoing transurethral bladder tumour excision (TURBT) were assigned randomly to two groups according to the maintenance anaesthetic agent received: sevoflurane (<jats:italic>n<\/jats:italic>= 41) or propofol (<jats:italic>n<\/jats:italic>= 41). The incidence of CRBD was evaluated at 0, 1, 6 and 24 h post\u2010operatively. The number of patients treated with a rescue medication (tramadol) for CRBD was noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of CRBD at post\u2010operative 1 h was lower in the sevoflurane group than that in the propofol group (59% vs. 85%;<jats:italic>P<\/jats:italic>= 0.007). The differences in CRBD were 27% and 22% at 0 and 6 h post\u2010operatively (<jats:italic>P<\/jats:italic>= 0.008 and 0.047, respectively). CRBD occurred in 27 (66%) patients in the sevoflurane group vs. 38 (93%) in the propofol group from 0 to 24 h post\u2010operatively (<jats:italic>P<\/jats:italic>= 0.005). The number of patients treated with tramadol was lower in the sevoflurane group (13 [22%] vs. 22 [54%];<jats:italic>P<\/jats:italic>= 0.044).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sevoflurane, as a maintenance in general anaesthesia, decreased the incidence of early post\u2010operative CRBD and tramadol requirements in patients undergoing TURBT, compared with propofol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12922","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T09:16:44Z","timestamp":1497345404000},"page":"773-780","source":"Crossref","is-referenced-by-count":19,"title":["Sevoflurane vs. propofol in post\u2010operative catheter\u2010related bladder discomfort: a prospective randomized study"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7783-7595","authenticated-orcid":false,"given":"H.\u2010C.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Keimyung University Dongsan Medical Centre Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4772-0780","authenticated-orcid":false,"given":"H.\u2010P.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Keimyung University Dongsan Medical Centre Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010H.","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Keimyung University Dongsan Medical Centre Daegu 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