{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:14Z","timestamp":1740124334319,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute fire smoke inhalation injury involves inflammatory mediators whose roles are poorly understood. We carried out a prospective observational study of fire smoke victims to identify clinical and biochemical markers that may predict pulmonary dysfunction and investigated possible correlations between dysfunction and cytokines in bronchoalveolar lavage (<jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>) fluid and blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients with respiratory and\/or neurological symptoms following acute fire smoke inhalation had pulmonary function tests and blood gas analyses performed on admission, at discharge, and after 3 months. Cytokines were measured using BioPlex\/<jats:styled-content style=\"fixed-case\">XM<\/jats:styled-content>ap technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On admission, 30 (75%) patients had dyspnea. Patients presenting with bronchial wheezing (<jats:italic>n<\/jats:italic> = 14) had significantly lower <jats:styled-content style=\"fixed-case\">PEF<\/jats:styled-content> (201 l\/min, 82\u2013360) than non\u2010wheezing patients (406 l\/min, 100\u2013683) (<jats:italic>n<\/jats:italic> = 16, <jats:italic>P<\/jats:italic> = 0.03). Bronchial wheezing predicted need for <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> treatment with <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 93.3 at 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.001) and was associated with gas exchange impairment, with mean p<jats:sub>a<\/jats:sub>O<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio 34.4 (11.8\u201349.8) <jats:styled-content style=\"fixed-case\">kP<\/jats:styled-content>a on admission and 21.3 (8.3\u201344.5) <jats:styled-content style=\"fixed-case\">kP<\/jats:styled-content>a 48 h later. Blood Hb<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content> also predicted <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> treatment, with OR = 1.58 at 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.001). Serum <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108, and <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101 were significantly higher in wheezing patients after 12\u201324 h compared with non\u2010wheezing patients and study controls. Cytokine levels were still elevated after 3 months. <jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content> fluid had significantly higher levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2, and G\u2010<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> compared with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In victims of fire smoke inhalation, pulmonary wheezing predicts inflammation, pulmonary dysfunction, respiratory failure, and need for intensive care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.12962","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T01:46:52Z","timestamp":1503020812000},"page":"1142-1154","source":"Crossref","is-referenced-by-count":1,"title":["Bronchial wheezing predicts inflammation and respiratory failure in fire smoke victims"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0972-1130","authenticated-orcid":false,"given":"E. R.","family":"Nakstad","sequence":"first","affiliation":[{"name":"Norwegian National Unit for CBRNE Medicine Department of Acute Medicine Oslo University Hospital Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. C. D.","family":"Aass","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Oslo Oslo Norway"},{"name":"Department of Medical Biochemistry Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Opdahl","sequence":"additional","affiliation":[{"name":"Norwegian National Unit for CBRNE Medicine Department of Acute Medicine Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wits\u00f8","sequence":"additional","affiliation":[{"name":"Norwegian Institute of Public Health Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Borchsenius","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Heyerdahl","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. H.","family":"Skj\u00f8nsberg","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Oslo Oslo Norway"},{"name":"Department of Pulmonary Medicine Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"47","article-title":"Inhalation injury","volume":"61","author":"Wise B","year":"2015","journal-title":"Can Fam Physician"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802053380604"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199601000-00016"},{"key":"e_1_2_9_5_1","unstructured":"Union E.White paper of Fire Safe Europe aisbl launched on 2 December 2014 in the European Parliament Brussels Belgium. Available at:http:\/\/firesafeeuropeeu\/wp-content\/uploads\/2015\/07\/europe-is-playing-with-fire-_-white-paper_fseu_03_12_2014pdf(accessed November 2016)."},{"key":"e_1_2_9_6_1","unstructured":"Administration USF.Civilian fire fatalities in residential buildings (2012\u20102014). Available at:https:\/\/www.usfa.fema.gov\/downloads\/pdf\/statistics\/v18i4.pdf(accessed 10 August 2017)."},{"key":"e_1_2_9_7_1","unstructured":"Administration USF.Civilian fire injuries in residential buildings (2012\u20102014). Available at:https:\/\/www.usfa.fema.gov\/downloads\/pdf\/statistics\/v18i5.pdf(accessed 10 August 2017)."},{"key":"e_1_2_9_8_1","first-page":"53","article-title":"Management of acute smoke inhalation injury","volume":"12","author":"Toon MH","year":"2010","journal-title":"Crit Care Resusc"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-7241-21-31"},{"key":"e_1_2_9_10_1","first-page":"125","article-title":"Pathophysiological basis of smoke inhalation injury","volume":"18","author":"Murakami K","year":"2003","journal-title":"News Physiol Sci"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.21012"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5669"},{"key":"e_1_2_9_13_1","first-page":"326","article-title":"Acute respiratory distress syndrome: new definition, current and future therapeutic options","volume":"5","author":"Fanelli V","year":"2013","journal-title":"J Thorac Dis"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.3.801"},{"key":"e_1_2_9_15_1","unstructured":"ClardyPF ManakerS PerryH.Carbon Monoxide Poisoning: UpToDate.2016. UpToDate. UpToDate. 2016. Available at:https:\/\/www.uptodate.com\/contents\/search?search=carbon-monoxide-%20%20poisoning&sp=&searchType=PLAIN_TEXT&source=USER_INPUT&searchControl=TOP_PULLDOWN&searchOffset=1&autoComplete=false&language=&max=0. Accessed 1 June 2017."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.111.2894.652"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2009.05.013"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199012001-00015"},{"key":"e_1_2_9_19_1","first-page":"422","article-title":"Smoke inhalation injury","volume":"1","author":"Demling RH","year":"1993","journal-title":"New Horiz"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-198412000-00007"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198703000-00017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12613"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2016.06.012"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHH.0000000000000160"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.107.5.1365"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.09.21"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(88)80334-9"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e3181923b71"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/15459624.2014.895372"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.21002"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2006.07.017"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3153"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.2.475"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0704(05)70056-7"},{"key":"e_1_2_9_35_1","first-page":"1309","article-title":"National Center for Environmental Health, CDC. Carbon monoxide\u2013related deaths\u2013United States, 1999\u20102004","volume":"56","author":"King M","year":"2007","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","unstructured":"UpToDate.Signs and symptoms of various concentrations of carboxyhemoglobin levels. Available at:https:\/\/www.uptodate.com\/contents\/image?imageKey=SURG%2F106164&topicKey=SURG%2F105477&rank=1~150&source=see_link&search=smoke-inhalation%20Accessed%202014%20Dec%208(accessed 10 August 2017). Reproduced from: Einhorn IN. Physiological and toxicological aspects of smoke produced during the combustion of polymeric materials. Environ Health Perspect 1975; 11:163.","DOI":"10.1289\/ehp.7511163"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(83)80209-1"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199112193252502"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00318-4"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041630102"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199601000-00004"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.12962","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.12962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T16:01:39Z","timestamp":1696521699000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.12962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,17]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/aas.12962"],"URL":"https:\/\/doi.org\/10.1111\/aas.12962","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"type":"print","value":"0001-5172"},{"type":"electronic","value":"1399-6576"}],"subject":[],"published":{"date-parts":[[2017,8,17]]}}}