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From experimental studies of regional ischemia\u2010reperfusion injury, advanced age is associated with larger infarct size, reduced organ function, and augmented oxidative stress. The objective of this study was to investigate the effect of age on cardiovascular function, oxidative stress, inflammation, and endothelial activation after CA representing global ischemia\u2010reperfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Aged (26\u00a0months) and young (5\u00a0months) rats were subjected to 8\u00a0min of asphyxia induced CA, resuscitated and observed for 360\u00a0min. Left ventricular pressure\u2010derived cardiac function was measured at baseline and 360\u00a0min after CA. Blood samples obtained at baseline, 120\u00a0min, and 360\u00a0min after CA were analyzed for IL\u20101\u03b2, IL\u20106, IL\u201010, TNF\u2010\u03b1, elastase, sE\u2010selectin, sL\u2010selectin, sI\u2010CAM1, hemeoxygenase\u20101 (HO\u20101) and protein carbonyl. Tissue samples of brain, heart, kidney, and lung were analyzed for HO\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cardiac function, evaluated by d<jats:italic>P<\/jats:italic>\/d<jats:italic>t<\/jats:italic><jats:sub>max<\/jats:sub> and d<jats:italic>P<\/jats:italic>\/d<jats:italic>t<\/jats:italic><jats:sub>min<\/jats:sub>, was decreased after CA in both young and aged rats, with no group differences. Mean arterial pressure increased after CA in young, but not old rats. Aged rats showed significantly higher plasma levels of elastase and sE\u2010selectin after CA, and there was a significant different development over time between groups for IL\u20106 and IL\u201010. Young rats showed higher levels of HO\u20101 in plasma and renal tissue after CA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a rat model of asphyxial CA, advanced age is associated with an attenuated hyperdynamic blood pressure response and increased endothelial activation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13014","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T10:17:08Z","timestamp":1509013028000},"page":"49-62","source":"Crossref","is-referenced-by-count":7,"title":["Impact of age on cardiovascular function, inflammation, and oxidative stress in experimental asphyxial cardiac arrest"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-9932","authenticated-orcid":false,"given":"N.","family":"Secher","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Aarhus University Hospital Aarhus C Denmark"},{"name":"Department of Internal Medicine Horsens Regional Hospital Horsens Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Center of Functionally Integrative Neuroscience Aarhus University Aarhus C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"T\u00f8nnesen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Aarhus University Hospital Aarhus C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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