{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T14:41:56Z","timestamp":1779201716924,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T00:00:00Z","timestamp":1508889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We hypothesized that, compared with propofol, desflurane prolongs the antegrade accessory pathway effective refractory period (<jats:styled-content style=\"fixed-case\">APERP<\/jats:styled-content>) in children undergoing radiofrequency catheter ablation for Wolff\u2010Parkinson\u2010White (<jats:styled-content style=\"fixed-case\">WPW<\/jats:styled-content>) syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this randomized crossover study, children aged 4.1\u221216.1\u00a0years undergoing radiofrequency catheter ablation for <jats:styled-content style=\"fixed-case\">WPW<\/jats:styled-content> syndrome were randomly divided into four groups according to the concentration of desflurane and anesthetics used in the first and the second electrophysiological studies (<jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>). After induction of general anesthesia with propofol and tracheal intubation, they received one of the following regimens: 0.5 minimum alveolar concentration (<jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content>) desflurane (first <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>) and propofol (second <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>) (Des0.5\u2010Prop group, <jats:italic>n<\/jats:italic>\u00a0=\u00a08); propofol (first <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>) and 0.5 <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> desflurane (second <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>) (Prop\u2010Des0.5 group, <jats:italic>n<\/jats:italic>\u00a0=\u00a09); 1 <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> desflurane (first <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>) and propofol (second <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>) (Des1.0\u2010Prop group, <jats:italic>n<\/jats:italic>\u00a0=\u00a010); propofol (first <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>) and 1 <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> desflurane (second <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>) (Prop\u2010Des1.0 group, <jats:italic>n<\/jats:italic>\u00a0=\u00a09). Radiofrequency catheter ablation was performed upon completion of <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>. Sample size was determined to detect a difference in the <jats:styled-content style=\"fixed-case\">APERP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Desflurane at 1.0 <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> significantly prolonged the <jats:styled-content style=\"fixed-case\">APERP<\/jats:styled-content> compared with propofol, but did not affect the sinoatrial conduction time, atrio\u2010His interval or atrioventricular node effective refractory period. Supraventricular tachycardia was induced in all children receiving propofol, but not induced in 1 and 4 children receiving 0.5 <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> and 1.0 <jats:styled-content style=\"fixed-case\">MAC<\/jats:styled-content> desflurane, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Desflurane enhances the refractoriness and may block the electrical conduction of the atrioventricular accessory pathway, and is therefore not suitable for use in children undergoing radiofrequency catheter ablation for <jats:styled-content style=\"fixed-case\">WPW<\/jats:styled-content> syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13023","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T10:02:43Z","timestamp":1508925763000},"page":"159-166","source":"Crossref","is-referenced-by-count":11,"title":["Electrophysiological effects of desflurane in children with Wolff\u2010Parkinson\u2010White syndrome: a randomized crossover study"],"prefix":"10.1111","volume":"62","author":[{"given":"H.","family":"Hino","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Osaka City General Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1111-7162","authenticated-orcid":false,"given":"Y.","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Osaka City General Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pediatric Electrophysiology Pediatric Medical Care Center Osaka City General Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Electrophysiology Pediatric Medical Care Center Osaka City General Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Osaka City Juso Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.70.278"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405263302103"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1093\/europace\/euu087","article-title":"Long\u2010term results of paediatric radiofrequency catheter ablation: a population\u2010based 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