{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:59:52Z","timestamp":1785895192762,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,29]],"date-time":"2017-10-29T00:00:00Z","timestamp":1509235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["305340"],"award-info":[{"award-number":["305340"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">INFECT<\/jats:styled-content> project aims to advance our understanding of the pathophysiological mechanisms in necrotizing soft tissue infections (<jats:styled-content style=\"fixed-case\">NSTI<\/jats:styled-content>s). The <jats:styled-content style=\"fixed-case\">INFECT<\/jats:styled-content> observational study is part of the <jats:styled-content style=\"fixed-case\">INFECT<\/jats:styled-content> project with the aim of studying the clinical profile of patients with <jats:styled-content style=\"fixed-case\">NSTI<\/jats:styled-content>s and correlating these to patient\u2010important outcomes. With this protocol and statistical analysis plan we describe the methods used to obtain data and the details of the planned analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">INFECT<\/jats:styled-content> study is a multicentre, prospective observational cohort study. Patients with <jats:styled-content style=\"fixed-case\">NSTI<\/jats:styled-content>s are enrolled in five Scandinavian hospitals, which are all referral centres for <jats:styled-content style=\"fixed-case\">NSTI<\/jats:styled-content>s. The primary outcomes are the descriptive variables of the patients. Secondary outcomes include identification of factors associated with 90\u2010day mortality and amputation; associations between affected body part, maximum skin defect and Laboratory Risk Indicator for Necrotizing Fasciitis (<jats:styled-content style=\"fixed-case\">LRINEC<\/jats:styled-content>) score and 90\u2010day mortality; 90\u2010day mortality in patients with and without acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">LRINEC<\/jats:styled-content> score of six and above or below six; and association between affected body part at arrival and microbiological findings. Exploratory outcomes include univariate analyses of baseline characteristics associations with 90\u2010day mortality. The statistical analyses will be conducted in accordance with the predefined statistical analysis plan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Necrotizing soft tissue infections result in severe morbidity and mortality. The <jats:styled-content style=\"fixed-case\">INFECT<\/jats:styled-content> study will be the largest prospective study in patients with <jats:styled-content style=\"fixed-case\">NSTI<\/jats:styled-content>s to date and will provide important data for clinicians, researchers and policy makers on the characteristics and outcomes of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13024","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T02:46:38Z","timestamp":1509331598000},"page":"272-279","source":"Crossref","is-referenced-by-count":39,"title":["Necrotizing soft tissue infections \u2013 a multicentre, prospective observational study (<scp>INFECT<\/scp>): protocol and statistical analysis plan"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-8971","authenticated-orcid":false,"given":"M. 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P.","family":"Martins dos Santos","sequence":"additional","affiliation":[{"name":"LifeGlimmer GmBH Berlin Germany"},{"name":"Laboratory of Systems and Synthetic Biology Wageningen University &amp; Research Wageningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Perner","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Norrby\u2010Teglund","sequence":"additional","affiliation":[{"name":"Centre for Infectious Medicine Karolinska Institutet Karolinska University Hospital Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Hyldegaard","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Centre of Head and Orthopaedics Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4786-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.05.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/511638"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3916-9"},{"key":"e_1_2_7_6_1","unstructured":"INFECT \u2013 EU\u2010FP7\u2010HEALTH \u2013 Systems medicine to understand severe soft tissue infections [Internet]. 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