{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T10:33:17Z","timestamp":1791369197280,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T00:00:00Z","timestamp":1515283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institut Paoli-Calmettes"},{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille"},{"name":"IBISA (Infrastructures Biologie Sant\u00e9 et Agronomie)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Organ failures are the main prognostic factors in septic shock. The aim was to assess classical clinico\u2010biological parameters evaluating organ dysfunctions at intensive care unit admission, combined with proteomics, on day\u201030 mortality in critically ill onco\u2010hematology patients admitted to the intensive care unit for septic shock.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective monocenter cohort study. Clinico\u2010biological parameters were collected at admission. Plasma proteomics analyses were performed, including protein profiling using isobaric Tag for Relative and Absolute Quantification (<jats:styled-content style=\"fixed-case\">iTRAQ<\/jats:styled-content>) and subsequent validation by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty consecutive patients were included. Day\u201030 mortality was 47%. All required vasopressors, 32% mechanical ventilation, 33% non\u2010invasive ventilation and 13% renal\u2010replacement therapy. <jats:styled-content style=\"fixed-case\">iTRAQ<\/jats:styled-content>\u2010based proteomics identified von Willebrand factor as a protein of interest. Multivariate analysis identified four factors independently associated with day\u201030 mortality: positive fluid balance in the first 24 h (odds ratio = 1.06, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.01\u20131.12, <jats:italic>P<\/jats:italic> = 0.02), severe acute respiratory failure (odds ratio = 6.14<jats:sub>,<\/jats:sub> 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.04\u201336.15, <jats:italic>P<\/jats:italic> = 0.04), von Willebrand factor plasma level &gt; 439 ng\/ml (odds ratio = 9.7, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.52\u201361.98, <jats:italic>P<\/jats:italic> = 0.02), and bacteremia (odds ratio = 6.98, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> = 1.17\u201341.6, <jats:italic>P<\/jats:italic> = 0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Endothelial dysfunction, revealed by proteomics, appears as an independent prognostic factor on day\u201030 mortality, as well as hydric balance, acute respiratory failure and bacteremia, in critically ill cancer patients admitted to the intensive care unit. Endothelial failure is underestimated in clinical practice and represents an innovative therapeutic target.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13060","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T04:42:42Z","timestamp":1515559362000},"page":"493-503","source":"Crossref","is-referenced-by-count":9,"title":["Early prognostic factors in septic shock cancer patients: a prospective study with a proteomic approach"],"prefix":"10.1111","volume":"62","author":[{"given":"D.","family":"Mokart","sequence":"first","affiliation":[{"name":"Polyvalent Intensive Care Unit Department of Anesthesiology and Critical Care Institut Paoli Calmettes Marseille France"},{"name":"Groupe de Recherche en R\u00e9animation Respiratoire en Onco\u2010H\u00e9matologie (GRRROH) Paris 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