{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:18:47Z","timestamp":1789402727679,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs L\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","award":["691901"],"award-info":[{"award-number":["691901"]}],"id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Various methods are used to reduce venous blood pressure in the hepato\u2010splanchnic circulation, and hence minimise blood loss during liver surgery. Previous studies show that combination of vasopressin and nitroglycerin reduces portal pressure and flow in patients with portal hypertension, and in this study we investigated this combination in patients with normal portal pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In all, 13 patients were studied. Measurements were made twice to confirm baseline (C1 and BL), during vasopressin infusion 4.8 U\/h (V), and during vasopressin infusion combined with nitroglycerin infusion (V + N). Portal venous pressure (PVP), hepatic venous pressure (HVP), central haemodynamics and arterial and venous blood gases were obtained at each measuring point, and portal (splanchnic) and hepato\u2010splanchnic blood flow changes were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vasopressin alone did not affect PVP, whereas HVP increased slightly. In combination with nitroglycerin, PVP decreased from 10.1 \u00b1 1.6 to 8.9 \u00b1 1.3 mmHg (<jats:italic>P<\/jats:italic> &lt; 0.0001), and HVP decreased from 7.9 \u00b1 1.9 to 6.2 \u00b1 1.3 mmHg (<jats:italic>P<\/jats:italic> = 0.001). Vasopressin reduced portal blood flow by 47 \u00b1 19% and hepatic venous flow by 11 \u00b1 18%, respectively. Addition of nitroglycerin further reduced portal\u2010 and hepatic flow by 55 \u00b1 13% and 30 \u00b1 13%, respectively. Vasopressin alone had minor effects on central haemodynamics, whereas addition of nitroglycerin reduced cardiac index (3.2 \u00b1 0.7 to 2.7 \u00b1 0.5; <jats:italic>P<\/jats:italic> &lt; 0.0001). The arterial\u2010portal vein lactate gradient was unaffected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of vasopressin and nitroglycerin decreases portal pressure and hepato\u2010splanchnic blood flow, and could be a potential treatment to reduce bleeding in liver resection surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13117","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T09:47:56Z","timestamp":1522057676000},"page":"953-961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vasopressin and nitroglycerin decrease portal and hepatic venous pressure and hepato\u2010splanchnic blood flow"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3198-7162","authenticated-orcid":false,"given":"E.","family":"Wis\u00e9n","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Sahlgrenska Academy University of Gothenburg Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Svennerholm","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine Sahlgrenska Academy University of Gothenburg Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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