{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:04:59Z","timestamp":1772640299343,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["305340"],"award-info":[{"award-number":["305340"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Necrotizing soft tissue infections (<jats:styled-content style=\"fixed-case\">NSTI<\/jats:styled-content>s) are rare but carry a high morbidity and mortality. The multicenter <jats:styled-content style=\"fixed-case\">INFECT<\/jats:styled-content> project aims to improve the understanding of the pathogenesis, clinical characteristics, diagnosis, and prognosis of <jats:styled-content style=\"fixed-case\">NSTI<\/jats:styled-content>s. This article describes the study outline and statistical analyses that will be used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Within the framework of <jats:styled-content style=\"fixed-case\">INFECT<\/jats:styled-content> project, patients with <jats:styled-content style=\"fixed-case\">NSTI<\/jats:styled-content> at 5 Scandinavian hospitals are enrolled in a prospective observational cohort study. The goal is to evaluate outcome and characteristics for patients with <jats:styled-content style=\"fixed-case\">NSTI<\/jats:styled-content> and diabetes compared to patients with <jats:styled-content style=\"fixed-case\">NSTI<\/jats:styled-content> without diabetes. The primary outcome is mortality at 90\u00a0days after inclusion. Secondary outcomes include days alive and out of <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> and hospital, <jats:styled-content style=\"fixed-case\">SAPS II<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SOFA<\/jats:styled-content> score, infectious etiology, amputation, affected body area, and renal replacement therapy. Comparison in mortality between patients with diabetes type 1 and 2 as well as between insulin\u2010treated and non\u2010insulin\u2013treated diabetes patients will be made. Clinical data for diabetic patients with <jats:styled-content style=\"fixed-case\">NSTI<\/jats:styled-content> will be reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study will provide important data on patients with <jats:styled-content style=\"fixed-case\">NSTI<\/jats:styled-content> and diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13130","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T14:54:19Z","timestamp":1524149659000},"page":"1171-1177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diabetes and necrotizing soft tissue infections\u2014A prospective observational cohort study: Statistical analysis plan"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6739-6730","authenticated-orcid":false,"given":"A.","family":"Ros\u00e9n","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Medicine Sahlgrenska University Hospital\/Ostra Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Arnell","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Medicine Sahlgrenska University Hospital\/Ostra Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-8971","authenticated-orcid":false,"given":"M. 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