{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:14:00Z","timestamp":1780442040751,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ALF Grants, Region \u00d6sterg\u00f6tland"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although hyperoncotic albumin may be used to recruit oedema, its effectiveness remains unclear. Therefore, this issue was studied during infusion experiments in healthy volunteers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Fifteen healthy volunteers (mean age 31\u00a0years) received an infusion of 3\u00a0mL\/kg of 20% albumin over 30\u00a0minutes. Their urinary excretion was recorded, and venous blood samples were taken to measure blood haemoglobin (Hb), haematocrit, colloid osmotic pressure as well as plasma albumin and sodium concentrations on 15 occasions over a period of 300\u00a0minutes. Plasma volume expansion was taken as the inverse of the fluid\u2010induced dilution of venous plasma, as given by the blood Hb concentration. Mass balance calculations were used to estimate the mobilisation of fluid from the tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Maximum plasma volume expansion was reached 20\u00a0minutes after completing an infusion of 20% albumin. Urinary excretion was effectively increased, and the mobilised fluid from the tissues at 300\u00a0minutes amounted to 3.4\u00a0\u00b1\u00a01.2\u00a0mL for each infused mL of 20% albumin, of which 19% was of intracellular origin. The urinary excretion correlated strongly with the amount of recruited fluid (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.87) and inversely with the plasma volume expansion (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.53).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The infusion of 20% albumin significantly increases the plasma volume by recruiting interstitial fluid. After completing the infusion, there is a delay of 20\u00a0minutes until maximum plasma dilution is reached, and the duration of the plasma volume expansion lasts far beyond 5\u00a0hours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.13150","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T01:59:42Z","timestamp":1527645582000},"page":"1255-1260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Recruitment of extravascular fluid by hyperoncotic albumin"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4865-6936","authenticated-orcid":false,"given":"M.","family":"Zdolsek","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Vrinnevihospital Norrk\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1528-3803","authenticated-orcid":false,"given":"R. G.","family":"Hahn","sequence":"additional","affiliation":[{"name":"Research Unit S\u00f6dert\u00e4lje Hospital S\u00f6dert\u00e4lje Sweden"},{"name":"Department of Clinical Sciences at Danderyd Hospital (KIDS) Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0079-7158","authenticated-orcid":false,"given":"J. H.","family":"Zdolsek","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care and Department of Medical and Health Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000000386"},{"key":"e_1_2_10_3_1","first-page":"963","article-title":"Colloids for fluid resuscitation: what is their role in patients with shock?","volume":"80","author":"Orbegozo Cortes D","year":"2014","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000150212.21651.79"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-8180(90)90077-G"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31827e154a"},{"key":"e_1_2_10_7_1","first-page":"257","article-title":"Effect of excessive infusion of saline solution on tissue oxygen transport","volume":"135","author":"Heughan C","year":"1972","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197501000-00009"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1896.sp000596"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200004000-00030"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer515"},{"key":"e_1_2_10_12_1","first-page":"224","article-title":"Prediction of blood volume in normal human adults","volume":"51","author":"Nadler SB","year":"1962","journal-title":"Surgery"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1987.tb02623.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990240202"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(01)00228-8"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2014(08)06"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.3.307"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13301"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040303"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000436"},{"key":"e_1_2_10_21_1","first-page":"319","volume-title":"Guyton and Hall Textbook of Medical Physiology","author":"Hall JE","year":"2015"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.13150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T10:25:31Z","timestamp":1694773531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.13150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,29]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/aas.13150"],"URL":"https:\/\/doi.org\/10.1111\/aas.13150","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733322039.793553210","asserted-by":"object"}]},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,29]]},"assertion":[{"value":"2017-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}