{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:22Z","timestamp":1740124342595,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Departmental funding only"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010operative sepsis considerably increases mortality, but the extent of pre\u2010operative sepsis in hip fracture patients and its consequences are sparsely elucidated. The aim of this study was to assess the association between pre\u2010operative sepsis and 30\u2010day mortality after hip fracture surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of data collected among 1894 patients who underwent hip fracture surgery in the Capital Region of Denmark in 2014 (<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>03201679). Data on vital signs, cultures and laboratory data were obtained. Sepsis was defined as a positive culture of any kind and presence of systemic inflammatory response syndrome within 24\u00a0hours and was assessed within 72\u00a0hours before surgery and 30\u00a0days post\u2010operatively. Primary outcome was 30\u2010day mortality. Secondary outcomes included length of hospital stay and admission to intensive care unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 144 (7.6%) of the hip fracture patients met the criteria for pre\u2010operative sepsis. The 30\u2010day mortality was 13.9% in patients with pre\u2010operative sepsis as compared to 9.0% in those without (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.69, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [1.00; 2.85], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.08). Patients with pre\u2010operative sepsis had longer hospital stays (median 10\u00a0days vs 9\u00a0days, mean difference 2.1 [<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 9.4] days, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03), and higher frequency of <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> admission (11.1% vs 2.7%, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.15, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [2.19; 7.87], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pre\u2010operative sepsis in hip fracture patients was associated with an increased length of hospital stay and tended to increase mortality. Pre\u2010operative sepsis in hip fracture patients merits more intensive surveillance and increased attention to timely treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13160","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T03:24:35Z","timestamp":1527218675000},"page":"1209-1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The association between pre\u2010operative sepsis and 30\u2010day mortality in hip fracture patients\u2014A cohort study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9125-4764","authenticated-orcid":false,"given":"S. S.","family":"M\u00f8rch","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Bispebjerg and Frederiksberg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tantholdt\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Bispebjerg and Frederiksberg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9065-4427","authenticated-orcid":false,"given":"N. E.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Bispebjerg and Frederiksberg Hospital University of Copenhagen Copenhagen Denmark"},{"name":"Centre for HR, Capital Region of Denmark Copenhagen Academy for Medical Education and Simulation Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9893-5573","authenticated-orcid":false,"given":"C. L.","family":"Duus","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Bispebjerg and Frederiksberg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Day Case Surgery Amager and Hvidovre Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. \u00d8.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Amager and Hvidovre Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. O.","family":"Jarl\u00f8v","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4885-4609","authenticated-orcid":false,"given":"C. 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