{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:26:32Z","timestamp":1762298792893,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T00:00:00Z","timestamp":1527638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005423","name":"Akademiska Sjukhuset","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>\n<jats:bold>Background<\/jats:bold>\n<\/jats:title><jats:p>Iatrogenic fluid overload is associated with increased mortality in the intensive care unit (ICU). Decisions on fluid therapy may, at times, be based on other factors than physiological endpoints. We hypothesized that because of psychological factors volume of available fluid bags would affect the amount of resuscitation fluid administered to ICU patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective intervention cross\u2010over study at 3 Swedish ICUs by replacing the standard resuscitation fluid bag of Ringer's Acetate 1000\u00a0mL with 500\u00a0mL bags (intervention group) for 5 separate months and then compared it with the standard bag size for 5\u00a0months (control group). Primary endpoint was the amount of Ringer's Acetate per patient during ICU stay. Secondary endpoints were differences between the groups in cumulative fluid balance and change in body weight, hemoglobin and creatinine levels, urine output, acute kidney failure (measured as the need for renal replacement therapy, RRT) and 90\u2010day mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six hundred and thirty\u2010five ICU patients were included (291 in the intervention group, 344 in the control group). There was no difference in the amount of resuscitation fluid per patient during the ICU stay (2200\u00a0mL [1000\u20104500 median IQR] vs 2245\u00a0mL [1000\u20105630 median IQR]), RRT rate (11 vs 9%), 90\u2010day mortality (11 vs 10%) or total fluid balance between the groups. The daily amount of Ringer's acetate administered per day was lower in the intervention group (1040 (280\u20102000) vs 1520 (460\u20103000) mL; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The amount of resuscitation fluid administered to ICU patients was not affected by the size of the available fluid bags. However, altering fluid bag size could have influenced fluid prescription behavior.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13161","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T04:45:38Z","timestamp":1527741938000},"page":"1261-1266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of resuscitation fluid bag size availability on volume of fluid administration in the intensive care unit"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9995-3132","authenticated-orcid":false,"given":"S.","family":"Horst","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Anesthesiology and Intensive Care Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kawati","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Anesthesiology and Intensive Care Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rasmusson","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care G\u00e4vle County Hospital G\u00e4vle Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pikwer","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research S\u00f6rmland Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Castegren","sequence":"additional","affiliation":[{"name":"Perioperative Medicine and Intensive Care Karolinska University Hospital and CLINTEC Karolinska Institute Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1976-4129","authenticated-orcid":false,"given":"M.","family":"Lipcsey","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Anesthesiology and Intensive Care Uppsala University Hospital Uppsala Sweden"},{"name":"Hedenstierna Laboratory, CIRRUS Department of Surgical Sciences, Anesthesiology and Intensive Care Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-3850-x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.05.017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-015-4172-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11682"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0020198"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10459-009-9182-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1191\/096032700678816142"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdh216"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062200"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdh200"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.2765"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12295"},{"volume-title":"Intravenous 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