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An important goal for haemodynamic monitoring and resuscitation is early detection of insufficient tissue perfusion. \u201cThe peripheral perfusion index\u201d reflects changes in peripheral perfusion and blood volume. We hypothesize that hip fracture patients are hypovolaemic with poor peripheral perfusion and accordingly respond to controlled fluid resuscitation. The peripheral perfusion index might reflect restricted tissue perfusion in spite of stable central haemodynamic variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective observational study assess to what extend hip fracture patients suffer from hypovolaemia and respond to a stroke volume\u2010guided fluid challenge. The secondary objectives are to evaluate correlation between the non\u2010invasive peripheral perfusion index and minimally invasive measures of stroke volume, changes in blood volume and near\u2010infrared spectroscopy determined tissue\u2010 and cerebral oxygenation and to compare results to prevalence of post\u2010operative complications including mortality. We will include 50 patients (&gt;65\u00a0years) presenting a hip fracture and treated in a multimodal fast\u2010track regimen when written informed consent is available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This is likely the first study to address pre\u2010operative haemodynamic monitoring and resuscitation in hip fracture patients where adequate resuscitation is easily missed. We aim to evaluate feasibility of pre\u2010operative stroke volume\u2010guided haemodynamic optimization in the context of minimally\u2010 and non\u2010invasive monitoring of peripheral perfusion and measure of blood volume.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13163","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T04:39:38Z","timestamp":1527741578000},"page":"1314-1320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pre\u2010operative haemodynamic monitoring and resuscitation in hip fracture patients: Protocol for a prospective observational study"],"prefix":"10.1111","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8408-7929","authenticated-orcid":false,"given":"M.","family":"Agerskov","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Hvidovre Hospital University of Copenhagen Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0819-106X","authenticated-orcid":false,"given":"H.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Abdominal Centre Rigshospitalet University of Copenhagen Kobenhavn Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"H\u00f8jlund","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Hvidovre Hospital University of Copenhagen Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. 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