{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:42:03Z","timestamp":1782902523680,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,5]],"date-time":"2018-08-05T00:00:00Z","timestamp":1533427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003744","name":"Stiftelsen Handlanden Hjalmar Svenssons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009673","name":"Gun och Bertil Stohnes Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009673","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hip fracture is a common injury in the elderly population and is associated with high morbidity and mortality. Intraoperative hypotension is commonly noted, and is often treated with vasopressors (VP), however, to what extent is unknown. We set out to examine retrospectively how many hip fracture\u2010patients received VP perioperatively and further to investigate if VP treatment is connected to increased mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Data on VP treatment were captured from medical and anaesthesia journals, and if so, data were investigated to find potential confounders. Patients were divided into (a) no VP, (b) VP by injection, (c) VP by infusion &lt;3 hours, and (d) VP by infusion \u22653 hours to achieve stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine hundred and ninety\u2010seven patients were included. About 80.4% received VP treatment. The 30\u2010day mortality rates in subgroups were 3.6%, 5.4%, 6.4% and 19.1% respectively. The 90\u2010day mortality rates were 6.7%, 10.3%, 11.6% and 30.3% respectively. Finally, the same patient groups had 365\u2010day mortality rates of 12.8%, 20.0%, 23.3% and 44.9% respectively. We found a significant increase in mortality (30\u201090\u2010365 days) in patients receiving VP infusion \u22653 hours, after adjusting for confounding factors. There was no increased mortality in patients treated by injection and by infusion &lt;3 hours after adjustment for confounding factors vs untreated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vasopressor treatment is common during hip fracture surgery. Patients treated with VP infusion \u22653 hours have increased mortality, while patients treated with injections or infusion &lt;3 hours have not. We suggest that the prolonged use of VP treatment is linked to increased mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.13215","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T03:32:16Z","timestamp":1533612736000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prolonged vasopressor support during hip\u2010fracture surgery is a risk factor for enhanced mortality"],"prefix":"10.1111","volume":"63","author":[{"given":"Johan","family":"Kristiansson","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Sahlgrenska University Hospital M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Sahlgrenska University Hospital M\u00f6lndal Sweden"},{"name":"Sahlgrenska Academy Gothenburg University Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hagberg","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Sahlgrenska University Hospital M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Dutkiewicz","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Sahlgrenska University Hospital M\u00f6lndal Sweden"},{"name":"Sahlgrenska Academy Gothenburg University Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Nellg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Sahlgrenska University Hospital M\u00f6lndal Sweden"},{"name":"Sahlgrenska Academy Gothenburg University Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,5]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Riksh\u00f6ft.\u00c5rsrapport 2015[cited 2017 1 June].http:\/\/rikshoft.se\/wp-content\/uploads\/2013\/07\/Arsrapport_2015.pdf. 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