{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:50:31Z","timestamp":1775040631087,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In free flap surgery, the maintenance of proper blood flow after anastomosis of flap pedicle vessels is important. Lipo\u2010prostaglandin E1 (lipo\u2010<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>1) has been empirically administered to prevent blood flow insufficiency in a free flap reconstruction. We tested our hypothesis that lipo\u2010<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>1 administration increases the arterial inflow of free flap. We also evaluated lipo\u2010<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>1\u2010related haemodynamic changes and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010seven patients who underwent free flap reconstruction were analysed. Lipo\u2010<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>1 was administered 10\u00a0minutes after the vascular anastomosis of the free flap. The maximal blood flow velocity was measured at the free flap pedicle artery before and 30\u00a0minutes after lipo\u2010<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>1 administration using duplex ultrasonography. The primary outcome was the difference in the maximal blood flow velocity before and 30\u00a0minutes after lipo\u2010<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>1 administration. The arterial blood pressure, heart rate, cardiac output, stroke volume variation, and pulse pressure variation were measured simultaneously. Lipo\u2010<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>1\u2010related complications such as hypotension, bradycardia, hypothermia, facial flushing, diarrhoea, apnoea, and seizure were also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The maximal blood flow velocity was significantly increased at 30\u00a0minutes after lipo\u2010<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>1 administration compared to the level before lipo\u2010<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>1 administration (mean (standard deviation): 26.3 (8.7)\u00a0cm\/s vs 22.5 (8.0)\u00a0cm\/s, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002). The haemodynamic variables were not significantly different before and 30\u00a0minutes after lipo\u2010<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>1 administration. No lipo\u2010<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>1\u2010related complications occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lipo\u2010<jats:styled-content style=\"fixed-case\">PGE<\/jats:styled-content>1 significantly increases the maximal blood flow velocity without complications in patients undergoing free flap reconstruction and may be an effective and safe method of maintaining adequate blood flow in these cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13217","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T08:23:02Z","timestamp":1532938982000},"page":"40-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Lipo\u2010prostaglandin E1 increases immediate arterial maximal flow velocity of free flap in patients undergoing reconstructive surgery"],"prefix":"10.1111","volume":"63","author":[{"given":"Seok\u2010Joon","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Anesthesiology St. Paul's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunsuk Peter","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joonho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai\u2010Hyun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Pio (Jp)","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-3053","authenticated-orcid":false,"given":"Young\u2010Kug","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Asan Medical Center University of Ulsan College of Medicine Seoul 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