{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T14:30:28Z","timestamp":1746196228843,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Perioperative hyperoxia has been linked to increased long\u2010term mortality. Vasoconstrictive and cellular side effects to hyperoxia have been suggested to increase the risk of coronary and cerebral ischemia. The aim of this post\u2010hoc analysis of a large randomized trial was to compare the effects of 80% vs 30% perioperative oxygen on the long\u2010term risk of stroke or transient cerebral ischemia (<jats:styled-content style=\"fixed-case\">TCI<\/jats:styled-content>) in patients undergoing abdominal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1386 patients were randomized to 80% or 30% perioperative oxygen during acute or elective open abdominal surgery. Median follow\u2010up was 3.9\u00a0years. Primary outcome was a composite of the long\u2010term occurrence of stroke or <jats:styled-content style=\"fixed-case\">TCI<\/jats:styled-content>. Secondary outcomes included long\u2010term mortality without stroke or <jats:styled-content style=\"fixed-case\">TCI<\/jats:styled-content>, and incidences of neurological admission, psychiatric admission, and dementia. Outcomes were analyzed in Cox regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stroke or <jats:styled-content style=\"fixed-case\">TCI<\/jats:styled-content> occurred in 20 (3.0%) patients given 80% oxygen vs 22 (3.2%) patients given 30% oxygen with an adjusted hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) of 0.96 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.52\u20101.76]. Composite secondary outcome of death, stroke, or <jats:styled-content style=\"fixed-case\">TCI<\/jats:styled-content> had a <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> of 1.21 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.00\u20101.47] for 80% compared to 30% oxygen. <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>s for secondary outcomes were <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.14 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.79\u20101.64] for neurological admission, 1.34 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.95\u20101.88] for psychiatric admission and 0.54 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.16\u20101.80] for dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Stroke or <jats:styled-content style=\"fixed-case\">TCI<\/jats:styled-content> did not seem related to perioperative inspiratory oxygen fraction. Due to few events, this study cannot exclude that perioperative hyperoxia increases risk of mortality, stroke, or <jats:styled-content style=\"fixed-case\">TCI<\/jats:styled-content> after abdominal surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13235","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T13:51:38Z","timestamp":1533131498000},"page":"164-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between perioperative hyperoxia and cerebrovascular complications after laparotomy\u2014A post\u2010hoc follow\u2010up study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-3276","authenticated-orcid":false,"given":"Emilie Katrine","family":"Kongebro","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Bispebjerg and Frederiksberg Hospital University of Copenhagen Copenhagen 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