{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:00:36Z","timestamp":1781593236856,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T00:00:00Z","timestamp":1533859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Orthostatic hypotension (OH<\/jats:styled-content>) and intolerance (OI<\/jats:styled-content>) are common findings in the early postoperative period after major surgery and may delay early mobilization. The mechanism of impaired orthostatic competence and OI<\/jats:styled-content> symptoms is not fully understood, and specific data after colorectal surgery with well\u2010defined perioperative care regimens and mobilization protocols are lacking. The aim of this study was to investigate the prevalence, possible risk factors and the impact of OI<\/jats:styled-content> in patients undergoing elective minimal invasive colorectal cancer resection.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective single\u2010centre study with an optimal enhanced recovery program and multimodal analgesic treatment. OI<\/jats:styled-content> and OH<\/jats:styled-content> were evaluated using a well\u2010defined mobilization protocol preoperatively and 6 hour and 24 hour postoperatively.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 100 patients were included in the data analysis. The overall median length of stay was 3 days (1\u201038). OI<\/jats:styled-content> was observed in 53% of the patients 6 hour postoperatively and in 24% at 24 hour. OI<\/jats:styled-content> at 6 hour postoperatively was associated with younger age, lower BMI<\/jats:styled-content>, and female gender. At 24 hour postoperatively, female gender and ASA<\/jats:styled-content> class >1 was associated with OI<\/jats:styled-content>. Opioid consumption and intravenous fluid during the first 24 hour was not associated with OI<\/jats:styled-content>. Postoperative complications were equally observed between patients with and without OI<\/jats:styled-content>. Although not statistically significant, patients with OI<\/jats:styled-content> at 24 hour postoperatively had prolonged LOS<\/jats:styled-content> (mean 4.0 vs 7.5 days, P<\/jats:italic> = 0.069) compared with patients without OI<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Postoperative orthostatic intolerance is a common problem during the first 24 hour following laparoscopic colorectal resection and may be followed by delayed recovery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13238","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T08:19:50Z","timestamp":1533889190000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Orthostatic intolerance in enhanced recovery laparoscopic colorectal resection"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7297-6537","authenticated-orcid":false,"given":"Jens R.","family":"Eriksen","sequence":"first","affiliation":[{"name":"Department of Surgery Colorectal Cancer Unit Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Munk\u2010Madsen","sequence":"additional","affiliation":[{"name":"Department of Surgery Colorectal Cancer Unit Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Kehlet","sequence":"additional","affiliation":[{"name":"Section for Surgical Pathophysiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"G\u00f6genur","sequence":"additional","affiliation":[{"name":"Department of Surgery Colorectal Cancer Unit Zealand University Hospital Roskilde 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