{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:12:47Z","timestamp":1757704367006,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Isocapnic hyperventilation (ICHV) may hasten emergence from general anesthesia but remains inadequately studied. We prospectively determined emergence time after sevoflurane anesthesia of variable duration with and without ICHV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 25 ASA I\u2010II patients, general anesthesia was maintained with one age\u2010adjusted MAC sevoflurane in O<jats:sub>2<\/jats:sub>\/air and target\u2010controlled remifentanil delivery. At the start of skin closure, the remifentanil effect\u2010site concentration was reduced to 1.5\u00a0ng\/mL, any residual neuromuscular block reversed, and once the remifentanil effect\u2010site concentration had decreased to 1.5\u00a0ng\/mL, remifentanil and sevoflurane administration was stopped, and the fresh gas flow increased above minute ventilation. Patients randomly received either normoventilation (n\u00a0=\u00a013) or ICHV (doubling minute ventilation while titrating CO<jats:sub>2<\/jats:sub> into the inspiratory limb to maintain isocapnia [n\u00a0=\u00a012]). Three early recovery end points were determined: time to proper response to verbal command; time to extubation; and time to stating one\u2019s name.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Demographics were the same in both groups. Recovery end points were reached faster in the ICHV group compared to the normoventilation group: time to proper response to verbal command was 7.6\u00a0\u00b1\u00a02.2 vs 9.9\u00a0\u00b1\u00a02.9\u00a0min (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03); time to extubation was 7.6\u00a0\u00b1\u00a02.6 vs 11.0\u00a0\u00b1\u00a02.4\u00a0min (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002); and time to stating one\u2019s name was 8.9\u00a0\u00b1\u00a02.8 vs 12.5\u00a0\u00b1\u00a02.6\u00a0min (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). Within each group, duration of anesthesia only marginally affected the times to reach these recovery end points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Isocapnic hyperventilation only had a small effect on emergence times after anesthesia, suggesting that isocapnic hyperventilation may have limited clinical benefits with modern potent inhaled anesthetics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13293","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T09:25:28Z","timestamp":1541496328000},"page":"455-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of isocapnic hyperventilation on early recovery after remifentanil\/sevoflurane anesthesia in O<sub>2<\/sub>\/air: A randomized trial"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8587-779X","authenticated-orcid":false,"given":"Andy","family":"De Baerdemaeker","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, VUB University Hospital Brussels  Jette Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Poelaert","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, VUB University Hospital Brussels  Jette Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Ross","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Christchurch Hospital and University of Otago, Christchurch Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre M.","family":"De Wolf","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan F. A.","family":"Hendrickx","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology\/CCM OLV Hospital Aalst Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-196903000-00012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000146961.70058.A1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg269"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000255074.96657.39"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000255199.43961.87"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000265849.33203.60"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12093"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181602dd4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181e2475c"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2011.02486.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2253-12-22"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeg132"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182a46d4e"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199801000-00006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000384"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000158611.15820.3D"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199902000-00022"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.13293","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T05:05:17Z","timestamp":1694667917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.13293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,6]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/aas.13293"],"URL":"https:\/\/doi.org\/10.1111\/aas.13293","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"type":"print","value":"0001-5172"},{"type":"electronic","value":"1399-6576"}],"subject":[],"published":{"date-parts":[[2018,11,6]]},"assertion":[{"value":"2018-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}