{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T21:37:34Z","timestamp":1763415454462,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T00:00:00Z","timestamp":1544140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A preliminary study has shown effective cancer pain relief by intrathecal betamethasone (ITB). However, further evidence is needed to support this new approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cancer patients with opioid\u2010resistant pain received lumbar intrathecal administration of betamethasone 2 or 3\u00a0mg once a week for 28\u00a0days. Immediate and short\u2010term analgesia (using a percentage pain reduction scale and a numerical rating scale, NRS) and long\u2010term analgesia (using NRS) were assessed. Patients were classified into two groups according to the most painful site of metastasis: vertebral column and\/or surrounding nerve plexus metastases (group\u00a0A) and other metastases distal from the vertebral column (group\u00a0B).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 104 patients received ITB. Pain relief was observed not only in the lower half but also in the upper half of the body. The proportion of group A patients who experienced immediate analgesia was 81% (47\/58), which was significantly greater than that of group B (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). A decrease in NRS scores 1\u00a0day after ITB administration was observed in significantly more patients in group A than in group B (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Long\u2010term analgesia was also recorded in a greater proportion of patients in group A than in group\u00a0B in the 7\u2010day (59%, 38\/64 vs 6%, 2\/33) and 28\u2010day periods (71%, 40\/56 vs 31%, 8\/26) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). No adverse effects related to neurotoxicity were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intrathecal injection of betamethasone produced analgesia for opioid\u2010resistant cancer pain, and may be a potent therapeutic option for intolerable pain from vertebral column and\/or surrounding nerve plexus metastases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13305","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T14:08:47Z","timestamp":1544191727000},"page":"659-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intrathecal betamethasone for cancer pain: A study of its analgesic efficacy and safety"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0194-2633","authenticated-orcid":false,"given":"Hitoshi","family":"Taguchi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Kansai 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