{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:31:30Z","timestamp":1747182690145,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","award":["20080063: LS0801-0019"],"award-info":[{"award-number":["20080063: LS0801-0019"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We have previously reported inconclusive results from a randomized controlled trial in elderly with hip\u2010fracture comparing intra\u2010operative goal\u2010directed therapy with routine fluid treatment. Now we aimed to describe and compare secondary outcomes at 4\u00a0months and 1\u00a0year follow\u2010up and to analyze the cost\u2010effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with hip fracture (age \u226570) were randomized for GDT or routine fluid treatment (RFT). The secondary outcomes were long\u2010term survival, complications, number of hospital readmissions, and quality of life (EQ\u20105D) changes. Additionally, cost effectiveness was analyzed by an analytic tool which combines the clinical effectiveness, quality of life changes and costs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patient data (GDT n\u00a0=\u00a074; RFT n\u00a0=\u00a075) were analyzed on an intention to treat basis. Statistically significant differences (GDT vs RFT) were not found considering survival (RR 0.76, 95%CI 0.45\u20101.28) and complications (RR 0.68, 95% CI 0.4\u20101.10) at 12\u00a0months. No statistically significant difference was found between hospital readmissions and quality of life changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The statistical uncertainty of risk reduction of negative outcomes and the large variability of the collected data indicate the need of further research in large sample sizes. To enable future health economic evaluation for decision support surrounding implementation of GDT, we suggest adding patient\u2010oriented outcomes in future trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13320","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T06:59:47Z","timestamp":1547794787000},"page":"610-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A 1\u2010year perspective on goal\u2010directed therapy in elderly with hip fracture: Secondary outcomes"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5048-4574","authenticated-orcid":false,"given":"Erzsebet","family":"Bartha","sequence":"first","affiliation":[{"name":"Perioperative Medicine and Intensive Care Karolinska University Hospital Huddinge, Stockholm Sweden"},{"name":"Department of Clinical Science, Intervention and Technology (CLINTEC) Karolinska Institute Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Davidson","sequence":"additional","affiliation":[{"name":"Centre for Medical Technology Assessment, Department of Medical and Health Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans E.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology (CLINTEC) Karolinska Institute Stockholm Sweden"},{"name":"Department of Orthopedics Karolinska University Hospital Huddinge, Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigridur","family":"Kalman","sequence":"additional","affiliation":[{"name":"Perioperative Medicine and Intensive Care Karolinska University Hospital Huddinge, Stockholm Sweden"},{"name":"Department of Clinical Science, Intervention and Technology (CLINTEC) Karolinska Institute Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes468"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu386"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-013-0496-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2017.11.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182655eb2"},{"volume-title":"Decision Modelling for Health Economic Evaluation","year":"2007","author":"Briggs A","key":"e_1_2_8_7_1"},{"key":"e_1_2_8_8_1","first-page":"Cd003004","article-title":"Perioperative fluid volume optimization following proximal femoral fracture","volume":"3","author":"Lewis SR","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09832-X"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.985"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.13320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.13320","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:48:10Z","timestamp":1694357290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.13320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,17]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/aas.13320"],"URL":"https:\/\/doi.org\/10.1111\/aas.13320","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"type":"print","value":"0001-5172"},{"type":"electronic","value":"1399-6576"}],"subject":[],"published":{"date-parts":[[2019,1,17]]},"assertion":[{"value":"2018-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}