{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:31:37Z","timestamp":1747182697111,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A decrease in lactate concentration over time during septic shock is associated with favourable outcomes. However, if this applies to hourly intervals during the initial time period in the ICU is unknown. The aim of this study was to investigate whether there is an early hourly reduction rate of lactate that is related to clinical outcome in septic shock patients treated in the ICU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of adult septic shock patients admitted to the ICU with an initial lactate level &gt;2\u00a0mmol\/L and receiving vasopressor was retrospectively analysed. Mean hourly reduction rate of lactate (\u0394Lact\/h) was calculated individually from all lactate concentrations measured from inclusion until normalization of lactate (\u22641.5\u00a0mmol\/L) within 24\u00a0hours. The mortality at 30\u00a0days following ICU admission was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1405 ICU admissions during 2\u00a0years, 104 patients were eligible. Mortality rate at 30\u00a0days was 34%. The optimal cut\u2010off values of baseline lactate and \u0394Lact\/h for 30\u2010day mortality were 4\u00a0mmol\/L and 2.5%\/h. When stratifying the patients by these cut\u2010points, those with baseline lactate\u00a0&gt;\u00a04\u00a0mmol\/L and \u0394Lact\/h\u00a0&lt;\u00a02.5%\/h had lowest probability of survival (27%). Multivariable logistic regression showed that \u0394Lact\/h &lt;2.5%\/h, baseline lactate &gt;4\u00a0mmol\/L and high Simplified Acute Physiology Score III were independent risk factors of 30\u2010day mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this retrospective pilot cohort, a mean reduction rate of lactate &lt;2.5%\/h within the first 24\u00a0hours of ICU stay was associated with an increased risk of 30\u2010day mortality in septic shock patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13366","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T08:06:01Z","timestamp":1554192361000},"page":"885-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optimal cut\u2010off for hourly lactate reduction in ICU\u2010treated patients with septic 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