{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T18:07:33Z","timestamp":1770919653659,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We evaluated whether the administration of sildenafil in children undergoing the TCPC operation shortened the interval from the operation to the removal of the pleural and peritoneal drains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the data of 122 patients who had undergone the TCPC operation between 2004 and 2014. Patients were divided into two groups on the basis of their treatments. Sildenafil was orally administered pre\u2010operatively in the morning of the procedure or within 24\u00a0hours after the TCPC operation to the sildenafil group (n\u00a0=\u00a048), which was compared to a control group (n\u00a0=\u00a060). Fourteen patients were excluded from the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The primary outcome measure was the time from the operation to the removal of the drains. The study groups had similar demographics. The median [interquartile range] time for the removal of drains (sildenafil group 11 [8\u201019] vs control group 11 [7\u201016] d, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.532) was comparable between the groups. The median [interquartile range] fluid balance on the first post\u2010operative day was significantly higher (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.001) in the sildenafil group compared with controls (47 [12\u2010103] vs 7 [\u22126\u201067] mL\u00a0kg<jats:sup>\u22121<\/jats:sup>). The first post\u2010operative day fluid balance was a significant predictor for a prolonged need for drains in the multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sildenafil administration, pre\u2010operatively or within 24\u00a0hours after the TCPC operation, did not reduce the required time for pleural and peritoneal drains but was associated with a significantly higher positive fluid balance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13431","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T20:37:52Z","timestamp":1562272672000},"page":"1384-1389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of sildenafil on pleural and peritoneal effusions after the TCPC operation"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-2399","authenticated-orcid":false,"given":"Tapio K.","family":"Koski","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care Children's Hospital, Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3365-5965","authenticated-orcid":false,"given":"Pertti K.","family":"Suominen","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Children's Hospital, Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Raissadati","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Department of Pediatric Cardiology Children's Hospital, Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna M.","family":"Knihtil\u00e4","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiina H.","family":"Ojala","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Department of Pediatric Cardiology Children's Hospital, Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka T.","family":"Salminen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery Children's Hospital, Helsinki University Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e3283396efc"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000701"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480907500213"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e328361390a"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951114001772"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000153"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.750596"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1429-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0538-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.06.042"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.06.121"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.03.034"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.05.047"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.02.010"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-2016-4"}],"container-title":["Acta 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