{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:38:29Z","timestamp":1775821109767,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["4108-00011A"],"award-info":[{"award-number":["4108-00011A"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005111","name":"Rigshospitalet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007420","name":"L\u00e6geforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007420","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The long\u2010term effects of stress ulcer prophylaxis with pantoprazole are unknown in ICU patients. We report 1\u2010year mortality outcome in the Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP\u2010ICU) trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the SUP\u2010ICU trial, acutely admitted adult ICU patients at risk of gastrointestinal bleeding were randomised to intravenous pantoprazole 40\u00a0mg vs placebo (saline) once daily during their ICU stay. We assessed mortality at 1 year and did sensitivity analyses according to the trial protocol and statistical analysis plan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3261 of the 3291 patients with available data (99.1%) were followed up at 1 year after randomisation; 1635 were allocated to pantoprazole and 1626 to placebo. At 1 year after randomisation, 610 of 1635 patients (37.3%) had died in the pantoprazole group as compared with 601 of 1626 (37.0%) in the placebo group (relative risk, 1.01; 95% confidence interval 0.92\u20101.10). The results were consistent in the sensitivity analysis adjusted for baseline risk factors and in those of the per\u2010protocol population. We did not observe heterogeneity in the effect of pantoprazole vs placebo on 1\u2010year mortality in the predefined subgroups, that is, patients with and without shock, mechanical ventilation, liver disease, coagulopathy, high disease severity (SAPS II &gt; 53) or in medical vs surgical ICU patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We did not observe a difference in 1\u2010year mortality among acutely admitted adult ICU patients with risk factors for gastrointestinal bleeding allocated to stress ulcer prophylaxis with pantoprazole or placebo during the ICU stay. (The SUP\u2010ICU trial was funded by Innovation Fund Denmark and others; ClinicalTrials.gov number, NCT02467621).<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13436","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T11:19:40Z","timestamp":1562584780000},"page":"1184-1190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pantoprazole in ICU patients at risk for gastrointestinal bleeding\u20141\u2010year mortality in the SUP\u2010ICU trial"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3602-4541","authenticated-orcid":false,"given":"S\u00f8ren","family":"Marker","sequence":"first","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"},{"name":"Centre for Research in Intensive Care (CRIC) Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Krag","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"},{"name":"Centre for Research in Intensive Care (CRIC) Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4668-0123","authenticated-orcid":false,"given":"Anders","family":"Perner","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"},{"name":"Centre for Research in Intensive Care (CRIC) Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rn","family":"Wetterslev","sequence":"additional","affiliation":[{"name":"Centre for Research in Intensive Care (CRIC) Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"},{"name":"Copenhagen Trial Unit, Centre for Clinical Intervention Research Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theis","family":"Lange","sequence":"additional","affiliation":[{"name":"Section of Biostatistics University of Copenhagen Copenhagen Denmark"},{"name":"Center for Statistical Science Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt P.","family":"Wise","sequence":"additional","affiliation":[{"name":"Department of Adult Critical Care University Hospital of Wales Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Borthwick","sequence":"additional","affiliation":[{"name":"Pharmacy Department Oxford University Hospitals NHS Foundation Trust Oxford 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University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bodil S.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Centre for Research in Intensive Care (CRIC) Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"},{"name":"Department of Anaesthesia and Intensive Care Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Elkmann","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Bestle","sequence":"additional","affiliation":[{"name":"Centre for Research in Intensive Care (CRIC) Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen Copenhagen Denmark"},{"name":"Department of Anaesthesia and Intensive Care Nordsj\u00e6lland Hospital University of Copenhagen Hiller\u00f8d Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn","family":"Arenkiel","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Holb\u00e6k Hospital Holb\u00e6k Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6157-5359","authenticated-orcid":false,"given":"Jon H.","family":"Laake","sequence":"additional","affiliation":[{"name":"Division of Emergencies and Critical Care, Department of Anaesthesiology, Rikshospitalet Medical Centre Oslo University Hospital Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maj K.","family":"Kamper","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Bispebjerg Hospital, University of Copenhagen Copenhagen 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