{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T07:53:41Z","timestamp":1785398021049,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010operative pain after an above\u2010knee amputation is often severe, and in the elderly patients the adverse effects of post\u2010operative opioids are evident. We hypothesized that continuous perineural local anesthetic infusion (CPI) combined to a wound infusion will reduce acute pain and opioid consumption compared to placebo after above knee amputation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010three patients going through an above knee amputation were recruited for this randomized, controlled trial. Two catheters were placed, one to the sciatic nerve sheath and one under the fasciae during the amputation. After two 10\u00a0mL boluses of ropivacaine 0.75% a post\u2010operative infusion of ropivacaine 0.2% or placebo (NaCl 0.9%) at 2\u00a0mL\/h was administered for 72\u00a0hours to both catheters. The primary outcome was average stump pain during the first 5\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean intensity of stump pain during the first five post\u2010operative days was 1.4 (0.8) in the CPI group and 1.9 (0.9) in the placebo group on VRS, mean (SD), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006. The opioid consumption on first five post\u2010operative days did not differ between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A combination of continuous perineural and wound local anesthetic infusion seems to diminish the intensity of stump pain after above knee amputation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13440","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T08:19:25Z","timestamp":1562573965000},"page":"1406-1412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Combination of perineural and wound infusion after above knee amputation: A randomized, controlled multicenter study"],"prefix":"10.1111","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1288-8495","authenticated-orcid":false,"given":"Hanna","family":"von Plato","sequence":"first","affiliation":[{"name":"Division of Perioperative Care, Department 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