{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:05:30Z","timestamp":1774422330076,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Mortality is high after an acute hip fracture (AHF) surgery. Are cognitive impairment and\/or altered levels of Alzheimer's Disease (AD)\u2010biomarkers in cerebrospinal fluid (CSF) predictors of mortality in AHF\u2010patients, as retrospective studies indicate?<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective single\u2010center study including 373 AHF\u2010patients, operated in spinal anesthesia. Cognitive status was evaluated by clinical dementia rating (CDR); CSF was analyzed for AD\u2010biomarker concentrations (total tau (T\u2010tau), phosphorylated tau (P\u2010tau), amyloid beta ratio (A\u03b242\/A\u03b240). CDR and biomarker levels were related to mortality up to one\u2010year post\u2010surgery, using univariate logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Survival analyses showed that mortality was associated to the degree of dementia. In the entire patient cohort 30\u2010, 90\u2010, and 365\u2010day mortality rates were 7.2%, 15.5%, and 25.5%, respectively, but only 2.7%, 5.5%, and 12.6%, for cognitively intact vs 16.3%, 31.7%, and 42.3% for demented patients (OR\u00a0=\u00a02.2\u20102.8 [CI\u00a0=\u00a01.6\u20104.9]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0001). High CSF T\u2010tau (OR\u00a0=\u00a01.19 [CI\u00a0=\u00a01.05\u20101.33]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) and low A\u03b242\/A\u03b240\u2010ratio (OR\u00a0=\u00a00.85 [CI\u00a0=\u00a00.74\u20100.97]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.017) were associated with increased 90\u2010day mortality. Analysis of 4 subgroups (Cognitive impairment \u00b1 and Biomarkers \u00b1) showed significant associations of dementia and CSF biomarker concentrations to mortality after an AHF. Even cognitively intact patients presenting with abnormal AD\u2010biomarkers showed an increased 90\u2010day mortality which, however, was statistically insignificant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cognitive impairment and altered CSF biomarker concentrations indicative of AD pathology can predict increased mortality in patients with an AHF, and so probably even before clinical dementia diagnosis by early biomarker analysis; a notion that may have substantial clinical implications by improving perioperative treatment and postoperative rehabilitation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13472","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T09:29:36Z","timestamp":1568194176000},"page":"93-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Dementia and CSF\u2010biomarkers for Alzheimer's disease predict mortality after acute hip fracture"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9059-7207","authenticated-orcid":false,"given":"Robert","family":"Dutkiewicz","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Sahlgrenska University Hospital M\u00f6lndal Sweden"},{"name":"Institute of Clinical Sciences Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital M\u00f6lndal Sweden"},{"name":"Department of Molecular Neuroscience UCL Institute of Neurology London UK"},{"name":"UK Dementia Research Institute at UCL London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Andreasson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Nellg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Sahlgrenska University Hospital M\u00f6lndal Sweden"},{"name":"Institute of Clinical Sciences Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq146"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)62167-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-016-0136-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-016-0329-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38643.663843.55"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1462"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-105"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.01.047"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33940-8"},{"key":"e_1_2_8_11_1","unstructured":"ASA Physical Status Classification System of the American Society of Anesthesiologists.After: Saklad M. 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