{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:23:51Z","timestamp":1786703031350,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs L\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to compare the effects of milrinone and levosimendan on right ventricular (RV) inotropy and lusitropy in patients after aortic valve replacement (AVR) for aortic stenosis, a procedure in which an abnormal postoperative RV function may be seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective, blinded trial, 31 patients were randomized to receive either milrinone (0.4 and 0.8\u00a0\u00b5g\/kg\/min, n\u00a0=\u00a016) or levosimendan (0.1 and 0.2\u00a0\u00b5g\/kg\/min, n\u00a0=\u00a015) after AVR for aortic stenosis. RV performance, afterload (pulmonary arterial elastance), RV strain, systolic (SR\u2010S) and early diastolic (SR\u2010E) strain rate were measured by pulmonary artery thermodilution catheterization and transoesophageal two\u2010dimensional speckle tracking echocardiography. To circumvent the indirect effects of inodilator\u2010induced hemodynamic changes on RV systolic and diastolic deformation, pulmonary arterial elastance, central venous pressure and heart rate were maintained constant by atrial pacing, plasma volume expansion with colloids and phenylephrine\u2010induced vasoconstriction during treatment with the inotropes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A dose\u2010dependent increase in stroke volume index and cardiac index by approximately 20% were seen with both agents at the highest doses, with no difference between groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.792 and 0.744, respectively). In both groups, RV strain and SR\u2010S dose\u2010dependently increased by 20% and 15%\u201019%, respectively, at the highest doses (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.742 and 0.259, respectively) with no difference between groups. SR\u2010E improved by both agents 20%\u201024% at the highest dose with no difference between groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.714).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The direct RV inotropic and lusitropic effects of levosimendan and milrinone were comparable at clinically relevant infusion rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13486","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T05:59:24Z","timestamp":1569477564000},"page":"193-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Levosimendan or milrinone for right ventricular inotropic treatment?\u2014A secondary analysis of a randomized trial"],"prefix":"10.1111","volume":"64","author":[{"given":"Martin","family":"Fredholm","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine at the Sahlgrenska Academy 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