{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:47:09Z","timestamp":1778813229242,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010operative pain management of hip fracture patients is complex. Femoral nerve block (FNB) is used for hip fractures to reduce pain and demand for systematic analgesia. The objective of the study was to systematically investigate the efficacy of single\u2010shot FNB for hip fracture patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five databases were searched from inception until 8 May 2019. We included randomized controlled trials (RCT's) assessing pain relief in patients with hip fractures. Intervention was pre\u2010operative FNB compared to any systemic analgesic (eg opioids, non\u2010steroidal anti\u2010inflammatory drugs or paracetamol). Primary outcomes assessed were pre\u2010operative pain and use of rescue analgesics. Secondary outcome was cognitive impairment. We present a bias assessment, a meta\u2010analysis and a grading of certainty of evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included five trials (n\u00a0= 254), where participants received FNB 30\u00a0minutes or more prior to surgery; all were judged as having high risk of bias. All studies found significantly decreased pain scores at least once in the intervention group compared to the control group. Meta\u2010analysis on the primary outcome of pain showed significance. Mean difference was \u22122.13 point (in cm) (CI:\u20103.53,\u20100.72) on visual analogue scale in the intervention group, but is judged low on certainty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The quantity of evidence supporting pre\u2010operative single\u2010shot FNB for hip fractures is very low, and the certainty of evidence supporting pre\u2010operative single\u2010shot FNB for hip fractures is low. No studies using ultrasound guided technique were identified. Data on non\u2010ultrasound guided FNB\u2019s suggest a decreased pain score compared to the use of systemic analgesia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13491","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T20:39:33Z","timestamp":1570653573000},"page":"23-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Pre\u2010operative femoral nerve block for hip fracture\u2014A systematic review with meta\u2010analysis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8377-0275","authenticated-orcid":false,"given":"C.","family":"Skjold","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Herlev Anaesthesia Critical and Emergency Care Science Unit Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-1544","authenticated-orcid":false,"given":"A. 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