{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:35:36Z","timestamp":1765280136566,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T00:00:00Z","timestamp":1573862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The \u201cParacetamol and Ibuprofen in Combination\u201d (PANSAID) trial showed that combining paracetamol and ibuprofen resulted in lower opioid consumption than each drug alone and we did not find an increase in risk of harm when using ibuprofen vs paracetamol. The aim of this subgroup analysis was to investigate the differences in benefits and harms of the interventions in different subgroups. We hypothesized that the intervention effects would differ in subgroups with different risk of pain or adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In these pre\u2010planned subgroup analyses of the PANSAID trial population, we assessed subgroup heterogeneity in intervention effects between (a) subgroups (sex, age, use of analgesics, American Society of Anesthesiologists (ASA) score, and type of anesthesia) and morphine consumption, and (b) subgroups (sex, age, use of non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs), and ASA score) and serious\u00a0adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Test of interaction between age and the pairwise comparison between paracetamol 1\u00a0g vs paracetamol 0.5\u00a0g\u00a0+\u00a0ibuprofen 200\u00a0mg (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.009) suggested lower morphine consumption in patients &gt;65\u00a0years. However, post hoc analyses of related outcomes showed no interaction for this pairwise comparison. All other tests of interaction regarding both benefit and harm were not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These pre\u2010planned subgroup analyses did not suggest that patients in the investigated subgroups benefitted differently from a basic non\u2010opioid analgesic regimen consisting of paracetamol and ibuprofen. Further, there was no evidence of subgroup heterogeneity regarding harm and use of ibuprofen. Because of reduced statistical power in subgroup analyses, we cannot exclude clinically relevant subgroup heterogeneity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13496","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T23:58:15Z","timestamp":1571961495000},"page":"245-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Benefits and harm of paracetamol and ibuprofen in combination for post\u2010operative pain: Pre\u2010planned subgroup analyses of the multicenter, randomized PANSAID trial"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4727-3132","authenticated-orcid":false,"given":"Kasper H.","family":"Thybo","sequence":"first","affiliation":[{"name":"Department of Anesthesiology N\u00e6stved\u2010Slagelse\u2010Ringsted Hospitals N\u00e6stved Denmark"},{"name":"Department of Anesthesiology Zealand University Hospital K\u00f8ge K\u00f8ge Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"H\u00e4gi\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology N\u00e6stved\u2010Slagelse\u2010Ringsted Hospitals N\u00e6stved Denmark"},{"name":"Department of Regional Health Research The Faculty of Health Sciences University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7778-1771","authenticated-orcid":false,"given":"J\u00f8rn","family":"Wetterslev","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit Centre for Clinical Intervention Research Dpt. 7812 Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen B.","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Bispebjerg and Frederiksberg Hospitals Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janus C.","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research The Faculty of Health Sciences University of Southern Denmark Odense Denmark"},{"name":"Copenhagen Trial Unit Centre for Clinical Intervention Research Dpt. 7812 Copenhagen University Hospital Copenhagen Denmark"},{"name":"Department of Internal Medicine Holb\u00e6k Hospital Holb\u00e6k Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Anker","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Gildhoj Private Hospital Br\u00f8ndby Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology N\u00e6stved\u2010Slagelse\u2010Ringsted Hospitals N\u00e6stved 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