{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:46Z","timestamp":1787013766029,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypotension during major surgery is frequent, resulting in increased need for observation in the post\u2010anaesthesia care unit and treatment including vasopressors and fluids. However, although severe hypotension in the immediate post\u2010operative recovery phase after major surgery is suggested to be related to increased morbidity and mortality, the underlying risk factors are not well described, hindering advancements in prevention and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective study assessing factors (age, gender, body\u2010mass index, cardiac co\u2010morbidity, haemoglobin, absolute and increase in c\u2010reactive protein on the first post\u2010operative day, bleeding, fluid balance at the end of surgery and the first post\u2010operative day) related to severe persistent hypotension (SPH) (SPH: need for noradrenaline to maintain a mean arterial blood pressure (MAP) &gt;65.0\u00a0mm Hg on the morning after surgery) and occurrence of other early (24\u00a0hours) complications. One hundred patients undergoing pancreaticoduodenectomy (PD) with pre\u2010operative high\u2010dose glucocorticoid and goal\u2010directed fluid therapy were enrolled and perioperative data collected from anaesthetic and medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010five patients had SPH, who had a significantly higher increase in CRP levels the morning after surgery (median 50\u00a0mg\u00a0L\n                      <jats:sup>\u22121<\/jats:sup>\n                      vs 41\u00a0mg\u00a0L\n                      <jats:sup>\u22121<\/jats:sup>\n                      , SPH vs non\u2010SPH, respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.028), and a significantly more positive fluid balance at discharge (median 1457\u00a0ml vs 1031\u00a0ml, respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.027) vs patients without SPH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Severe persistent hypotension after PD was associated with significantly increased inflammatory response and increased need for fluids. Future studies should investigate the effect of further inflammatory control in PD to improve haemodynamics and morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.13522","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T05:00:36Z","timestamp":1576126836000},"page":"455-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Persistent severe post\u2010operative hypotension after pancreaticoduodenectomy is related to increased inflammatory response"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4843-9595","authenticated-orcid":false,"given":"Sandra E. Taylor","family":"Pitter","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Centre for Cancer and Organ Diseases Rigshospitalet, Copenhagen Denmark"},{"name":"Section for Surgical Pathophysiology Juliane Marie Centre Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Kehlet","sequence":"additional","affiliation":[{"name":"Section for Surgical Pathophysiology Juliane Marie Centre Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten P.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Surgery Centre for Cancer and Organ Diseases Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Bundgaard\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Centre for Cancer and Organ Diseases Rigshospitalet, Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Storkholm","sequence":"additional","affiliation":[{"name":"Department of Surgery Centre for Cancer and Organ Diseases Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7131-2461","authenticated-orcid":false,"given":"Eske K.","family":"Aasvang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Centre for Cancer and Organ Diseases Rigshospitalet, Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001985"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.14172"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0375-9393.17.11878-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001691"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60687-5"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13983"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2017.07.190"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23662"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183313"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1704500507"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2012.02689.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000465"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-8180(94)00001-K"},{"key":"e_1_2_9_15_1","unstructured":"WetterslevJ HornA PedrsenBD BeckA DichJO.Danish Society of Anaesthesia and Intensive Care Medicine: Recommendations for preparation of discharge criteria from the anaesthesia department to the surgical department following anaesthesia in Denmark version 5. 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