{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:19:31Z","timestamp":1782321571844,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Parenteral opioids are used for pain relief in labour but there are little data for oxycodone in this context. The aim of this study was to evaluate the efficacy, foetal exposure and safety of subcutaneous oxycodone in the latent phase of labour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This pragmatic trial included 76 parturients, who received subcutaneous oxycodone for pain relief in the latent phase of labour according to the hospital protocol: an initial dose 0.1\u00a0mg\/kg, and a second dose, 0.05\u00a0mg\/kg, could be administered four hours later. Pain intensity and pain relief were assessed using a numerical rating scale of 0\u201010. After delivery, blood samples from the maternal and umbilical veins were collected, and plasma concentrations of oxycodone and its main metabolites were quantified using UPLC\u2010MS\/MS. The Apgar scores and maternal and neonatal adverse effects were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The foetal exposure at birth was low, the median oxycodone and oxymorphone umbilical vein plasma concentrations were 1.2\u00a0ng\/mL (range 0.21\u20107.8) and 0.14\u00a0ng\/mL (0\u20100.26), respectively. Pain scores decreased substantially, from a median pain score of 7\/10 before oxycodone to median scores of 5\/10 at 30\u00a0minutes after administration, 5\/10 at 60\u00a0minutes and 6\/10 at 120\u00a0minutes. The median Apgar score was 9 (range 2\u201010) at 1\u00a0minute and 9 (6\u201010) at 5\u00a0minutes. Maternal adverse effects were mild, and there were no oxycodone\u2010related neonatal adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Subcutaneous oxycodone provided effective analgesia during the latent phase of labour. Newborn exposure at birth was low, and oxycodone was well\u2010tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13550","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T08:47:40Z","timestamp":1579250860000},"page":"685-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oxycodone for pain management in the latent phase of labour \u2013 A pragmatic trial"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5248-4690","authenticated-orcid":false,"given":"Mari","family":"Kinnunen","sequence":"first","affiliation":[{"name":"School of Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Kokki","sequence":"additional","affiliation":[{"name":"School of Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Hautaj\u00e4rvi","sequence":"additional","affiliation":[{"name":"Admescope Ltd Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa","family":"Tuovinen","sequence":"additional","affiliation":[{"name":"School of Medicine University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1501-7537","authenticated-orcid":false,"given":"Merja","family":"Kokki","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Kuopio University Hospital Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359105313502695"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3783-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.srhc.2015.01.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.05.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-536X.2010.00447.x"},{"key":"e_1_2_9_7_1","first-page":"CD007396","article-title":"Parenteral opioids for maternal pain management in labour","volume":"6","author":"Smith LA","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000277"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-00731-3"},{"key":"e_1_2_9_10_1","unstructured":"International Narcotics Control Board.Narcotic drugs \u2014 Estimated world requirements for 2019 \u2014 Statistics for 2017.2018.www.incb.org. Accessed June 2019 28."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1965.tb00075.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2012.00884.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-018-2013-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wombi.2017.10.001"},{"key":"e_1_2_9_15_1","volume-title":"An Evidence\u2010Based Resource for Pain Relief","author":"McQuay H","year":"1998"},{"key":"e_1_2_9_16_1","first-page":"2365","article-title":"The role of the anesthesiologist in reducing neonatal mortality","volume":"55","author":"Apgar V","year":"1955","journal-title":"N Y State J Med"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198205000-00003"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet337"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000444441.04111.1d"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1204000209"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1994.tb04324.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-017-2122-6"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13378"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.5.468.33347"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2005.07.009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/204946370800200205"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181b0f0bb"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12268"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.13550","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T08:26:47Z","timestamp":1694075207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.13550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,27]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/aas.13550"],"URL":"https:\/\/doi.org\/10.1111\/aas.13550","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,27]]},"assertion":[{"value":"2019-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}