{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:58:37Z","timestamp":1789084717111,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["#86626"],"award-info":[{"award-number":["#86626"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009738","name":"Anna och Edwin Bergers Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Little is known about the value of biomarkers for prognostication in hip fracture patients. The main objective of the present study was to assess if biomarkers add useful information to an existing risk score for prediction of 30\u2010day mortality in patients suffering from out of hospital hip fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a prospective observational single centre study, association between plasma concentration of ninety\u2010two biomarkers at admission and 30\u2010day mortality was analysed using logistic regression adjusted for risk factors included in Nottingham Hip Fracture Score (NHFS). Biomarkers associated with the outcome in the adjusted analysis were further evaluated by calculating the net reclassification improvement (NRI) and the change in area under the receiver operating characteristics curve (AUC) relative to the NHFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      997 patients were included. Sixty\u2010two patients died within 30\u00a0days (6.2%). Eleven biomarkers were associated with 30\u2010day mortality in adjusted analysis. Of these biomarkers Growth Differentiation Factor\u201015 (GDF\u201015) had NRI for the primary outcome (12.1%; 95% CI: 1.2\u201023.3) and Carbohydrate Antigen 125 (CA\u2010125) improved the AUC relative to NHFS (improvement: 0.05; 95% CI: 0.01\u20100.10,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.027). Both CA\u2010125 and GDF\u201015 improved the AUC for a composite outcome of 30\u2010day mortality and cardiovascular complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adding GDF\u201015 or CA\u2010125 to the Nottingham Hip Fracture Score improves the discrimination with regard to predicting 30\u2010day mortality and may help to identify a subgroup of hip fracture patients with a particularly poor prognosis. The value of these biomarkers should be explored in further studies to confirm clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aas.13581","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T23:43:56Z","timestamp":1585698236000},"page":"920-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel biomarkers for prediction of outcome in hip fracture patients\u2014An exploratory study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9844-8628","authenticated-orcid":false,"given":"Magnus H.","family":"Jonsson","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Medicine Ystad Hospital Ystad Sweden"},{"name":"Department of Clinical Sciences Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Hommel","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Clinical Epidemiology Unit Orthopaedics Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizbet","family":"Todorova","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Department of Emergency and Internal Medicine Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bentzer","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Department of Anaesthesia and Intensive Care Helsingborg Hospital Helsingborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3768-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4666-7"},{"key":"e_1_2_8_4_1","unstructured":"BoultonC.Royal College of Physicians National Hip Fracture Database annual report 2016. Edited by.BoultonC London UK:Royal College of Physicians.2016."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.2018.1428436"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13131"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14225"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2014.11.004"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.10.025"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13418"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq405"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.97B1.34670"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes187"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38643.663843.55"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2008.01.025"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182827322"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep139"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009416"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-017-5245-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20170109-02"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.06.038"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2018.1514650"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181622bca"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095192"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1975.tb00927.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen236"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc3057"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex148"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2010.340"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001141"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2013-0055"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.255174"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00629.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2013.05.003"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.979740"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078797"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105759"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-019-0503-7"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/2050-7771-1-25"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2008.04.012"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.30287"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.06.007"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9398"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.12.018"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2017.04.014"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800780327"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.13581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.13581","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T21:20:12Z","timestamp":1693948812000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.13581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,14]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/aas.13581"],"URL":"https:\/\/doi.org\/10.1111\/aas.13581","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,14]]},"assertion":[{"value":"2020-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}