{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T23:04:24Z","timestamp":1769555064279,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies have reported substantially decreased hospital mortality for sepsis, but data are\u00a0scarcer\u00a0on outcomes after hospital discharge. We studied mortality up to 1\u00a0year in Swedish intensive care unit (ICU) patients with and without sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic and medical data for all registered adult general ICU patients admitted between 01\u201001\u20102008 and 30\u201009\u20102016 were retrieved from the Swedish Intensive Care Registry and linked with the National Patient Register for comorbidity data and the Cause of Death Register for death dates. The population was divided in two cohorts; (a) Patients with a diagnosis of severe sepsis or septic shock and (b) All other ICU patients. Crude yearly mortality was calculated, and logistic regression was used to analyse predictors of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>28\u00a0886 sepsis and 221\u00a0941 nonsepsis ICU patients were identified. In the sepsis cohort, in 2008 unadjusted mortality was 32.6% at hospital discharge, 32.7% at 30\u00a0days, 39% at 90\u00a0days and 46.8% at 365\u00a0days. In 2016, mortality was 30.5% at hospital discharge, 31.9% at 30\u00a0days and 38% at 90\u00a0days. Mortality at 365\u00a0days was 45.3% in 2015. Corresponding nonsepsis mortality was 15.4%, 16.2%, 20% and 26% in 2008 and 15.6%, 17.1%, 20.7% and 26.7% in 2016\/2015. No consistent decrease in odds of mortality was seen in the adjusted analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mortality in severe sepsis and septic shock is high, with more than one in three patients not surviving three months after ICU admission, and adjusted mortality has not decreased convincingly in Sweden 2008\u20102016.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> The study was registered prospectively, ClinicalTrials.gov ID: NCT03489447.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13587","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T05:58:56Z","timestamp":1585634336000},"page":"967-975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Mortality after Severe Sepsis and Septic Shock in Swedish Intensive Care Units 2008\u20102016\u2014A nationwide observational 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