{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:37:40Z","timestamp":1772109460618,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Anesthetic techniques can affect perioperative neuroendocrine function. The objective of this study was to compare 3\u2010month post\u2010operative neuroendocrine functional outcomes between sevoflurane and propofol anesthesia in patients undergoing endoscopic transsphenoidal surgery (ETS) for removal of non\u2010functional pituitary adenomas (NFPAs) retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 356 patients who underwent ETS for removal of NFPAs under sevoflurane\u2010remifentanil anesthesia (sevoflurane group, n\u00a0=\u00a0103) or propofol\u2010remifentanil anesthesia (propofol group, n\u00a0=\u00a0253), 92 patients in each group were selected and their 3\u2010month post\u2010operative neuroendocrine functional outcomes (primary outcome measure) were compared after propensity score matching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall changes in post\u2010operative 3\u2010month neuroendocrine function compared to pre\u2010operative baseline did not differ between the sevoflurane and propofol groups (worsened: 32.6% vs 29.3%, persistently decreased: 9.8% vs 12.0%, improved: 12.0% vs 20.7%, normalized: 9.8% vs 12.0%, persistently normal: 18.5% vs 19.6%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.400). The incidence of pituitary hormone deficiency at 3 months post\u2010operatively did not differ between the sevoflurane and propofol groups (adrenocorticotropic hormone deficiency: 18.5% vs 17.4%, <jats:italic>P<\/jats:italic> = 1.000; thyroid\u2010stimulating hormone deficiency: 10.9% vs 3.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.081; gonadotropin deficiency: 54.3% vs 48.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.555; growth hormone deficiency: 45.7% vs 48.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.768; panhypopituitarism: 1.1% vs 1.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients undergoing ETS for removal of NFPAs, the effects of both sevoflurane\u2010remifentanil and propofol\u2010remifentanil anesthetic techniques on post\u2010operative 3\u2010month neuroendocrine functional outcomes were similar, suggesting that propofol and sevoflurane can be freely used in such patients in terms of post\u2010operative intermediate\u2010term neuroendocrine functional outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13646","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T19:42:41Z","timestamp":1590781361000},"page":"1063-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of anesthetics on post\u2010operative 3\u2010month neuroendocrine function after endoscopic transsphenoidal non\u2010functional pituitary adenoma surgery"],"prefix":"10.1111","volume":"64","author":[{"given":"Hyongmin","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Hospital Seoul National University College of Medicine Jongno\u2010gu Seoul 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