{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:32:16Z","timestamp":1747182736827,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Angiotensin\u2010converting enzyme inhibitor (ACE\u2010I) and angiotensin\u2010receptor blocker (ARB) users may be associated with increased mortality in patients with post\u2010operative acute kidney injury (AKI), but data are limited. We studied whether users of ACE\u2010I\/ARBs with AKI after colorectal cancer surgery (CRC) were associated with increased 1\u2010year mortality after AKI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This population\u2010based cohort study in Northern Denmark included patients with AKI within 7\u00a0days after CRC surgery during 2005\u20102014. From reimbursed prescriptions, patients were classified as ACE\u2010I\/ARB current, former, or non\u2010users. We computed the cumulative 30\u2010day and 1\u2010year mortality after AKI with 95% confidence intervals (95% CI) using the Kaplan\u2010Meier method (1\u2014survival function). Hazard ratios (HRs) comparing mortality in current and former users with non\u2010users were computed by Cox proportional hazards regression analyses, controlling for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 10\u00a0713 CRC surgery patients. A total of 2000 patients had AKI and were included. Thirty\u2010day mortality was 16.5% (95% CI 13.7\u201019.8), 16.2% (95% CI 11.3\u201022.8), and 13.4% (95% CI 11.6\u201015.4) for current, former, and non\u2010users. Adjusted HR was 1.26 (95% CI 0.96\u20101.65) and 1.19 (95% CI 0.78\u20101.82) for current and former users compared with non\u2010users. One\u2010year mortality rates were 26.4% (95% CI 22.9\u201030.4), 29.8% (95% CI 23.2\u201037.8), and 24.7% (95% CI 22.4\u201027.2) in current, former, and non\u2010users. Compared with non\u2010users, the adjusted 1\u2010year HR for death in current and former users were 1.29 (95% CI 0.96\u20101.73) and 1.11 (95% CI 0.91\u20101.35).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on our findings, current users of ACE\u2010I\/ARB may possibly have a small increase in mortality rate in the year after post\u2010operative AKI, although the degree of certainty is low.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13654","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T19:54:40Z","timestamp":1592423680000},"page":"1262-1269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Renin\u2010angiotensin system blockers and 1\u2010year mortality in patients with post\u2010operative acute kidney injury"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0879-9836","authenticated-orcid":false,"given":"Charlotte","family":"Slagelse","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Anaesthesiology Regional Hospital West Jutland Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Gammelager","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Intensive Care Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene H.","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen D.","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, School of Medicine, School of Medicine University of California San Francisco Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik T.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian F.","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-024817"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10498"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000425"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.11.021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00031.x"},{"issue":"3","key":"e_1_2_9_7_1","first-page":"1","article-title":"Clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"2013","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO","year":"2012","journal-title":"Kidney Inter"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5160-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12284"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2017.09.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.2-12.v1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S37587"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S17901"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S99481"},{"key":"e_1_2_9_17_1","first-page":"1","article-title":"Improving global outcomes (KDIGO) acute kidney injury work group","volume":"2","author":"Kidney Disease KDIGO","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.036533"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000290588.29668.38"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc2872"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_9_22_1","first-page":"1","article-title":"KDIGO clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"KDIGO","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00825.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2393"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-11-83"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.13654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.13654","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T16:15:49Z","timestamp":1693930549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.13654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,9]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/aas.13654"],"URL":"https:\/\/doi.org\/10.1111\/aas.13654","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"type":"print","value":"0001-5172"},{"type":"electronic","value":"1399-6576"}],"subject":[],"published":{"date-parts":[[2020,7,9]]},"assertion":[{"value":"2019-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}