{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:35:24Z","timestamp":1781804124448,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A variety of rapid response systems (RRSs) based on the systematic assessment of vital signs and laboratory tests have been developed to reduce hospital mortality through the early detection of alarm signs, while deterioration may still be reversible. This study aimed to determine the association between alarm signs and post\u2010operative hospital mortality during post\u2010operative days (POD) 0\u20103 in patients undergoing non\u2010cardiac surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective observational study used data from the registry of a single tertiary academic hospital. The study population included patients who were \u226518\u00a0years old, admitted between 1 January 2013 and 30 June 2018 for non\u2010cardiac surgery, and subsequently transferred to the general ward.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 116\u00a0329 patients were included in the analysis. Among them, 10\u00a0099 patients (8.7%) showed positive alarm criteria and triggered the RRS in the post\u2010operative ward during POD 0\u20103. In the multivariate logistic regression model, PaO<jats:sub>2<\/jats:sub> &lt;55\u00a0mm\u00a0Hg, SpO<jats:sub>2<\/jats:sub> &lt;90%, and total CO<jats:sub>2<\/jats:sub> &lt;15\u00a0mmol\/L were associated with a 3.57\u2010, 3.46\u2010, and 12.53\u2010fold increase in post\u2010operative hospital mortality, respectively. Moreover, when compared to the no alarm signs group, patients with 1, 2, 3, and \u22654 alarm signs showed a 2.79\u2010, 2.76\u2010, 6.54\u2010, and 20.02\u2010fold increase in hospital mortality, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased post\u2010operative hospital mortality was found to be associated with alarm signs detected by the RRS during POD 0\u20103. The post\u2010operative alarm signs detected by the RRS may therefore be useful in determining high\u2010risk patients who require medical interventions in the surgical ward.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13668","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:02:20Z","timestamp":1594677740000},"page":"1431-1437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Post\u2010operative alarm signs in the rapid response system and hospital mortality after non\u2010cardiac surgery"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7814-4253","authenticated-orcid":false,"given":"In\u2010Ae","family":"Song","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun 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