{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:59:31Z","timestamp":1789545571768,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T00:00:00Z","timestamp":1597622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010operative hypoxemia is prevalent in hospitalized patients and may adversely affect recovery. However, little data exist on the post\u2010discharge phase or details on duration, severity and potential risk factors. Thus, we investigated the incidence and risk factors for severe desaturation during the first post\u2010operative week after THA\/TKA by continuous nocturnal oxygen saturation monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was a secondary analysis of a prospective cohort study of 112 patients undergoing fast\u2010track THA\/TKA. Patients with known sleep apnoea were excluded. Oxygen saturation and heart rate were recorded by a wireless wrist\u2010worn pulse oximeter 2 nights before and 7 nights after surgery. Data on demographics, opioid consumption and cognitive function were collected from medical charts, patient diaries and clinical testing respectively. The primary outcome was occurrence of severe desaturation defined as periods with saturation &lt;85% lasting \u226510\u00a0minutes. Secondary outcomes included description of various saturation levels and relevant risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Severe oxygen desaturation occurred in 35% of the patients during the first post\u2010operative week. Duration and severity of hypoxemic episodes increased after the first post\u2010operative day. Pre\u2010operative episodes of hypoxemia significantly increased the risk of post\u2010operative hypoxemic events (OR 2.4\u20104.4, CI 0.4\u201046), while pre\u2010 and post\u2010operative opioid use, age, gender, ASA classification, type of surgery or anaesthesia were significantly related to the development of post\u2010operative hypoxemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One third of the patients suffered from increased and prolonged episodes of severe nocturnal hypoxemia during the first week after THA\/TKA discharge. Increased risk for severe hypoxemic episodes was related to pre\u2010operative hypoxemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13671","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:06:04Z","timestamp":1594677964000},"page":"1405-1413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hypoxemia following hospital discharge after fast\u2010track hip and knee arthroplasty \u2013 A prospective observational study subanalysis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0248-4489","authenticated-orcid":false,"given":"I. E.","family":"Luna","sequence":"first","affiliation":[{"name":"The Lundbeck Centre for fast\u2010track Hip and Knee Arthroplasty Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kehlet","sequence":"additional","affiliation":[{"name":"The Lundbeck Centre for fast\u2010track Hip and Knee Arthroplasty Copenhagen Denmark"},{"name":"Section of Surgical Pathophysiology Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department of Electrical Engineering Technical University of Denmark Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. R.","family":"Wede","sequence":"additional","affiliation":[{"name":"The Lundbeck Centre for fast\u2010track Hip and Knee Arthroplasty Copenhagen Denmark"},{"name":"Department of Orthopaedics Gentofte\u2010Herlev Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. J.","family":"Hoevsgaard","sequence":"additional","affiliation":[{"name":"The Lundbeck Centre for fast\u2010track Hip and Knee Arthroplasty Copenhagen Denmark"},{"name":"Department of Orthopaedics Vejle Hospital Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7131-2461","authenticated-orcid":false,"given":"E. K.","family":"Aasvang","sequence":"additional","affiliation":[{"name":"The Lundbeck Centre for fast\u2010track Hip and Knee Arthroplasty Copenhagen Denmark"},{"name":"Section of Surgical Pathophysiology Rigshospitalet University of Copenhagen Copenhagen Denmark"},{"name":"Department of Anaesthesia Center for Cancer and Organ Failure Rigshospitalet University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"A5553","article-title":"Temporal trends in length of stay and readmissions after fast\u2010track hip and knee arthroplasty","volume":"66","author":"Petersen PB","year":"2019","journal-title":"Dan Med J"},{"issue":"1","key":"e_1_2_6_3_1","first-page":"e54","article-title":"Enhanced postoperative recovery: good from afar, but far from good?","volume":"75","author":"Kehlet H","year":"2020","journal-title":"Anaesthesia"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14691"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000836"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13173"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PTS.0000000000000307"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2018.09.023"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh208"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/72.3.286"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-010-9279-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000541"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-6576.2003.00240.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12667"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.04.010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-018-0185-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.99B9.BJJ-2016-1343.R1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2019.03.021"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/20.11.991"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2012.03.011"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh180"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000049"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e31828d0173"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0903"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew029"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35797-3"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004053"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.4360"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453674.2018.1517487"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.5.1552"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.13671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.13671","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:21:33Z","timestamp":1693876893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.13671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,17]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/aas.13671"],"URL":"https:\/\/doi.org\/10.1111\/aas.13671","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,17]]},"assertion":[{"value":"2020-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}