{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:01:50Z","timestamp":1778540510369,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["0062998"],"award-info":[{"award-number":["0062998"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["60473019"],"award-info":[{"award-number":["60473019"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Anaesthesiol Scand"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus\u20102 has caused a pandemic of coronavirus disease (COVID\u201019) with many patients developing hypoxic respiratory failure. Corticosteroids reduce the time on mechanical ventilation, length of stay in the intensive care unit and potentially also mortality in similar patient populations. However, corticosteroids have undesirable effects, including longer time to viral clearance. Clinical equipoise on the use of corticosteroids for COVID\u201019 exists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The COVID STEROID trial is an international, randomised, stratified, blinded clinical trial. We will allocate 1000 adult patients with COVID\u201019 receiving \u226510\u00a0L\/min of oxygen or on mechanical ventilation to intravenous hydrocortisone 200\u00a0mg daily vs placebo (0.9% saline) for 7\u00a0days. The primary outcome is days alive without life support (ie mechanical ventilation, circulatory support, and renal replacement therapy) at day 28. Secondary outcomes are serious adverse reactions at day 14; days alive without life support at day 90; days alive and out of hospital at day 90; all\u2010cause mortality at day 28, day 90, and 1\u00a0year; and health\u2010related quality of life at 1\u00a0year. We will conduct the statistical analyses according to this protocol, including interim analyses for every 250 patients followed for 28\u00a0days. The primary outcome will be compared using the Kryger Jensen and Lange test in the intention to treat population and reported as differences in means and medians with 95% confidence intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The COVID STEROID trial will provide important evidence to guide the use of corticosteroids in COVID\u201019 and severe hypoxia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aas.13673","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T19:14:36Z","timestamp":1595358876000},"page":"1365-1375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Low\u2010dose hydrocortisone in patients with COVID\u201019 and severe hypoxia (COVID STEROID) trial\u2014Protocol and statistical analysis plan"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1127-9599","authenticated-orcid":false,"given":"Marie Warrer","family":"Petersen","sequence":"first","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1840-1596","authenticated-orcid":false,"given":"Tine Sylvest","family":"Meyhoff","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Helleberg","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6536-0504","authenticated-orcid":false,"given":"Maj\u2010Brit N\u00f8rregaard","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Granholm","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-9715","authenticated-orcid":false,"given":"Carl Johan Steensen","family":"Hjorts\u00f8","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Steen","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6378-9673","authenticated-orcid":false,"given":"Morten Hylander","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Buhl","family":"Hjortrup","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mik","family":"Wetterslev","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5221-3938","authenticated-orcid":false,"given":"Gitte Kingo","family":"Vesterlund","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibeke Lind","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Anaesthesiology Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Tjelle","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Hvidovre Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Benfield","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hvidovre Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte Suppli","family":"Ulrik","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Hvidovre Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Sofie","family":"Andreasen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Herlev Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Mohr","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Gentofte Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten H.","family":"Bestle","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Nordsj\u00e6llands Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lone Musaeus","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Zealand University Hospital K\u00f8ge Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette Friberg","family":"Hitz","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Endocrinology Zealand University Hospital K\u00f8ge Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Zealand University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene Surland","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Zealand University Hospital Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care N\u00e6stved\u2010Slagelse\u2010Ringsted Hospital Slagelse Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoffer Grant","family":"S\u00f8lling","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Viborg Hospital Viborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Craveiro","family":"Br\u00f8chner","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Kolding Hospital Kolding Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-145X","authenticated-orcid":false,"given":"Bodil Steen","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"},{"name":"Department of Anaesthesia and Intensive Care Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Str\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Cronhjort","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecka Rubenson","family":"Wahlin","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Jakob","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Cioccari","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Inselspital Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balasubramanian","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Hammond","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivekanand","family":"Jha","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales New Delhi India"},{"name":"Manipal Academy of Higher Education Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila Nainan","family":"Myatra","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Critical Care and Pain Tata Memorial Hospital Homi Bhabha National Institute Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Gluud","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit Centre for Clinical Intervention Research Copenhagen University Hospital Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theis","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Public Health Section of Biostatistics University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4668-0123","authenticated-orcid":false,"given":"Anders","family":"Perner","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Copenhagen University Hospital Copenhagen Denmark"},{"name":"Collaboration for Research in Intensive Care (CRIC) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Coronavirus Disease 2019 (COVID\u201019)","author":"World Health Organization","year":"2020"},{"key":"e_1_2_7_3_1","volume-title":"Center for Systems Science and Engineering at Johns Hopkins University"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"key":"e_1_2_7_5_1","volume-title":"Report of the WHO\u2010China Joint Mission on Coronavirus Disease 2019 (COVID\u201019)","author":"World Health Organization (WHO)","year":"2020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0994"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1996"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004363"},{"issue":"382","key":"e_1_2_7_11_1","first-page":"1708","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"2020","author":"Guan WJ","year":"2019","journal-title":"N Engl J Med"},{"issue":"5","key":"e_1_2_7_12_1","first-page":"475","article-title":"Clinical course and outcomes of critically ill patients with SARS\u2010CoV\u20102 pneumonia in Wuhan, China: a single\u2010centered, retrospective, observational study. Lancet","volume":"8","author":"Yang X","year":"2020","journal-title":"Respir Med"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06057-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5197-6"},{"key":"e_1_2_7_15_1","first-page":"4637","article-title":"Effect of different doses and time\u2010courses of corticosteroid treatment in patients with acute respiratory distress syndrome: a meta\u2010analysis","volume":"18","author":"Sun S","year":"2019","journal-title":"Exp Ther Med"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59732-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","unstructured":"World Health Organization (WHO).Clinical management of severe acute respiratory infection (SARI) when COVID\u201019 disease is suspected.2020.https:\/\/www.who.int\/publications\/i\/item\/clinical\u2010management\u2010of\u2010covid\u201019. Accessed May 2 2020.","DOI":"10.15557\/PiMR.2020.0003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa478"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-3-201302050-00583"},{"key":"e_1_2_7_20_1","volume-title":"WMA Declaration of Helsinki \u2010 Ethical Principles for Medical Research involving Human Subjects","author":"World Medical Association","year":"2013"},{"key":"e_1_2_7_21_1","unstructured":"The Internation Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) Expert Working Group. Guideline for Good Clinical Practice E6(R2).2016."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.11.011"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-011-9903-x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-013-2949-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12917"},{"key":"e_1_2_7_27_1","article-title":"A novel high\u2010power test for continuous outcomes truncated by death","author":"Kryger Jensen A","year":"2019","journal-title":"arXiv"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h2622"},{"key":"e_1_2_7_29_1","unstructured":"ICH Steering Committee. International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. ICH Harmonised Tripartite. Guideline for Statistical Principles for Clinical Trials re."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4431"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530245"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001282"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_7_34_1","volume-title":"Multifactorial Adaptive Platform Trial for Community\u2010 Acquired Pneumonia (REMAP\u2010CAP)"},{"key":"e_1_2_7_35_1","unstructured":"Targeted Steroids for ARDS Due to COVID\u201019 Pneumonia: A Pilot Randomized Clinical Trial (NCT04360876).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04360876?term=COVID+STEROID&draw=2&rank=3"},{"key":"e_1_2_7_36_1","unstructured":"Steroid Dosing by bioMARker Guided Titration in Critically Ill Patients With Pneumonia (SMART) (NCT03852537).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03852537?term=COVID+STEROID&draw=2&rank=4"},{"key":"e_1_2_7_37_1","unstructured":"Glucocorticoid Therapy for COVID\u201019 Critically Ill Patients With Severe Acute Respiratory Failure (NCT04244591).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04244591?term=COVID+STEROID&draw=2&rank=5"},{"key":"e_1_2_7_38_1","unstructured":"Prophylactic Corticosteroid to Prevent COVID\u201019 Cytokine Storm (NCT04355247).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04355247?term=COVID+STEROID&draw=2&rank=7"},{"key":"e_1_2_7_39_1","unstructured":"Efficacy of Methylprednisolone for Patients With COVID\u201019 Severe Acute Respiratory Syndrome (MP\u2010C19) (NCT04323592).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04323592?term=COVID+STEROID&draw=2&rank=13"},{"key":"e_1_2_7_40_1","unstructured":"Methylprednisolone in the Treatment of Patients With Signs of Severe Acute Respiratory Syndrome in Covid\u201019 (MetCOVID) (NCT04343729).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04343729?term=COVID+methylprednisolone&draw=2&rank=3"},{"key":"e_1_2_7_41_1","unstructured":"Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID\u201019 (DEXA\u2010COVID19) (NCT04325061).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04325061?term=COVID+and+dexa&draw=2&rank=1"},{"key":"e_1_2_7_42_1","unstructured":"Community\u2010Acquired Pneumonia : Evaluation of Corticosteroids (CAPE_COD) (NCT02517489).https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02517489?term=COVID+hydrocortisone&draw=2&rank=5"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12090"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9266"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5696"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705835"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-0715"},{"key":"e_1_2_7_48_1","unstructured":"International Comittee of Medical Journal Editors (ICMJE). Recommendations for the Conduct Reporting Editing and Publication of Scholarly work in Medical Journals.http:\/\/www.icmje.org\/recommendations\/. Accessed May 5 2020."},{"key":"e_1_2_7_49_1","unstructured":"University of Oxford.Press release on 16 June 2020: Low\u2010cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID\u201019.https:\/\/www.recoverytrial.net\/files\/recovery_dexamethasone_statement_160620_v2final.pdf. Accessed June 16 2020."},{"key":"e_1_2_7_50_1","article-title":"Effect of Dexamethasone in Hospitalized Patients with COVID\u201019. Preliminary report","author":"Horby P","year":"2020","journal-title":"medRxiv"}],"container-title":["Acta Anaesthesiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faas.13673","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13673","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aas.13673","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aas.13673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T16:15:58Z","timestamp":1693930558000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aas.13673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,30]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/aas.13673"],"URL":"https:\/\/doi.org\/10.1111\/aas.13673","archive":["Portico"],"relation":{},"ISSN":["0001-5172","1399-6576"],"issn-type":[{"value":"0001-5172","type":"print"},{"value":"1399-6576","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,30]]},"assertion":[{"value":"2020-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}